Design,Synthesis and Synergistic Effects of Novel Derivatives of Solanesol

作     者：WANG Jian-hong WANG Chao-jie GAN Ying DU Gang-jun ZHAO Jin 

作者机构：Key Lab of Special Functional Material College of Chemistry and Chemical Technology Medical College Henan Unversity Kaifeng 475001 P. R. China 

基　　金：Supported by the National Natural Science Foundation of China(No.20472016) the Natural Science Foundation ofHenan Province,China(Nos.0423031800 and 512001300) the Key Technologies R&D Programme of Henan Province,China(No.072102270004) 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)

年 卷 期：2007年第23卷第4期

页      码：417-420页

摘      要：To further explore the biological activities of solanesylamine derivatives, several novel solanesylpiperazinotri-amines and their amides were designed and synthesized, the chemical structures of target compounds were confirmed by IR, ^1H NMR, MS, and element analysis. The in vitro antitumor activities of the synthetic compounds were as-sessed by MTT test on L1210 and CHO cells. The preliminary results showed that at low micromolar concentrations these compounds exhibit obvious toxicity against tumor cells, and the synergistic effect on clinical antitumor agent in-dicated that at noncytotoxic concentrations, they also evidently enhance the curative effect of vincristine（VCR）. The synergistic effects of compounds 4a, 4c, and 9 were even superior to that of reference compound N,N＇-bis（3,4-dime-thoxybenzyl） -N- solanesyl-ethylenediamine （ SDB ）.

主 题 词：Solanesylpiperazinotriamine Antitumor activity Synergistic effect 

学科分类：1007[医学-药学类] 10[医学] 

核心收录：

D　O　I：10.1016/S1005-9040(07)60090-7

馆 藏 号：203840171...