Designing General Anesthetics That Have a Better Safety Profile

作     者：Robert B. Raffa Joseph V. Pergolizzi Jr. Robert Taylor Jr. 

作者机构：Neumentum Inc.，Palo AltoCAUSA College of Pharmacy University of Arizona Tucson AZ USA Temple University School of Pharmacy Philadelphia PA USA NEMA Research Inc. Naples FL USA. 

出 版 物：《Pharmacology & Pharmacy》 (药理与制药（英文）)

年 卷 期：2019年第10卷第10期

页      码：407-415页

摘      要：General anesthetics constitute some of the most important and widely-used therapeutic drugs in the pharmacotherapeutic armamentarium. They are routinely used effectively and with adequate precaution-safety throughout the world for a multitude of clinical applications, predominantly as adjunctive agents for surgical procedures. Nevertheless, they have potential adverse effects (such as a drop in blood pressure and the inhibition of steroid production), particularly in vulnerable populations such as the very young and the frail elderly. It would be desirable therefore to have alternative agents that are just as efficacious, but have a better safety profile in a broader spectrum of patients. Toward this end, an anesthetic based on a unique chemical core (viz., an N-arylpyrrole derivative) has been reported in preclinical models to produce anesthetic effects without hemodynamic suppression. This lead could pave the way for new general anesthetics that are safer and easier to use.

主 题 词：General Anesthetic Intravenous Drug Discovery GABAA Receptor Molecular Modeling 

学科分类：0202[经济学-财政学类] 02[经济学] 020205[020205] 

D　O　I：10.4236/pp.2019.1010033

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