Evaluation of corneal cell growth on tissue engineering materials as artificial cornea scaffolds

作     者：Hai-Yan Wang Rui-Hua Wei Shao-Zhen Zhao 

作者机构：Department of OphthalmologyShijiazhuang No.1 Hospital Department of OphthalmologyTianjin Medical UniversityEye Hospital 

基　　金：National Natural Science Foundation of China(No.50973082) 

出 版 物：《International Journal of Ophthalmology(English edition)》 (国际眼科杂志（英文版）)

年 卷 期：2013年第6卷第6期

页      码：873-878页

摘      要：The keratoprosthesis(KPro;artificial cornea)is a special refractive device to replace human cornea by using heterogeneous forming materials for the implantation into the damaged eyes in order to obtain a certain *** main problems of artificial cornea are the biocompatibility and stability of the tissue particularly in penetrating *** current studies of tissue-engineered scaffold materials through comprising composites of natural and synthetic biopolymers together have developed a new way to artificial *** a wide agreement that the long-term stability of these devices would be greatly improved by the presence of cornea cells,modification of keratoprosthesis to support cornea cells remains *** of the studies on corneal substrate materials and surface modification of composites have tried to improve the growth and biocompatibility of cornea cells which can not only reduce the stimulus of heterogeneous materials,but also more importantly continuous and stable cornea cells can prevent the destruction of *** necrosis of stroma and spontaneous extrusion of the device,allow for maintenance of a precorneal tear layer,and play the role of ensuring a good optical surface and resisting bacterial *** a result,improvement in corneal cells has been the main aim of several recent investigations;some effort has focused on biomaterial for its well biological properties such as promoting the growth of cornea *** purpose of this review is to summary the growth status of the corneal cells after the implantation of several artificial corneas.

主 题 词：artificial cornea keratoprosthesis tissue-engineered scaffold corneal cells collagen fibrin amniotic membrane biomaterial 

学科分类：1002[医学-临床医学类] 100212[100212] 10[医学] 

核心收录：

D　O　I：10.3980/j.issn.2222-3959.2013.06.23

馆 藏 号：203885053...