Design and strategy for manufacturing kidney organoids

作     者：Masaki Nishikawa Yasuyuki Sakai Norimoto Yanagawa Masaki Nishikawa;Yasuyuki Sakai;Norimoto Yanagawa

作者机构：Department of Chemical System EngineeringSchool of EngineeringUniversity of TokyoRm.5A01Engineering Bldg.3Hongo 7‑3‑1BunkyoTokyo 113‑8656Japan Medical and Research ServicesGreater Los Angeles Veterans Affairs Healthcare System at SepulvedaNorth HillsCAUSA David Geffen School of MedicineUniversity of California at Los AngelesLos AngelesCAUSA 

基　　金：Funding was provided by Japan Society for the Promotion of Science(Grant-in-Aid for Research Activity Start-up) the Chau-Li Foundation 

出 版 物：《Bio-Design and Manufacturing》 (生物设计与制造（英文）)

年 卷 期：2020年第3卷第1期

页      码：7-14页

摘      要：Despite a continuing increase in the number of patients suffering from chronic kidney disease,currently available treatments for these patients,such as dialysis and kidney transplantation,are *** kidney is also a critical target organ vulnerable to the toxicity of various new drugs,and the lack of a reliable in vitro culture model imposes a severe limitation on drug *** the development of induced pluripotent stem cells(iPSCs)revolutionized strategies in biomedical fields,the complexity of the kidney imposed additional challenge to the application of this technology in kidney ***,the recent advancement in our understanding on the developmental origin of kidney progenitor cells and the mechanisms of their reciprocal induction and self-organization has boosted research in kidney *** since then has demonstrated that kidney organoids derived from iPSCs can serve as a useful model for drug discovery and toxicity screening,as well as for disease modeling,especially in combination with gene editing ***,attempts at kidney organoid implantation in animals have suggested their potential as an alternative source of kidney *** this review,we summarize recent progress on the generation of kidney organoids,as well as the obstacles that remain.

主 题 词：Kidney organoid Kidney development iPSC Progenitor cell Self-organization Regenerative medicine 

学科分类：08[工学] 080502[080502] 0805[工学-能源动力学] 

核心收录：

D　O　I：10.1007/s42242-020-00060-0

馆 藏 号：203885472...