Design, Sonosynthesis, Quantum-Chemical Calculations, and Evaluation of New Mono-and Bis-pyridine Dicarbonitriles as Antiproliferative Agents

作     者：Wael Abdelgayd Ahmed Arafa Modather F.Hussein Wael Abdelgayd Ahmed Arafa;Modather F.Hussein

作者机构：Chemistry DepartmentCollege of ScienceJouf UniversityP.O.Box 2014SakakaAljoufKingdom of Saudi Arabia Chemistry DepartmentFaculty of ScienceFayoum UniversityP.O.Box 63514Fayoum CityEgypt Chemistry DepartmentFaculty of ScienceAl-Azhar UniversityAsyut branchEgypt 

基　　金：supported by the Jouf University through a research grant 634/39 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2020年第38卷第5期

页      码：501-508页

摘      要：A highly efficient,simple,and clean single-step sonosynthetic procedure has been sophisticated for assembling new series of mono-and bis-pyridine dicarbonitriles from ketones,HCl,and *** presented protocol is applicable for the preparation of a broad range of uniquely substituted pyridine dicarbonitriles and seems to be superior in comparison with other previously reported *** antiproliferative impact of the newly synthesized derivatives was screened towards three representative cancer cell lines(MCF-7,A549,and HCT116).Most of the evaluated derivatives showed a moderate to excellent anti-proliferative activity towards the selected cell *** these,compounds 4h,4k,10,12a,and 12b showed both potent anticancer activity(ICs058μM)on non-tumorigenic cells(MCF-10A and NCM460),suggesting their promising potential to be lead molecules for future antitumor drug *** structure-activity relationships have been also ***,quantum chemical studies based on Density Functional Theory(DFT)of the synthesized compounds were investigated and found to be consistent with the in vitro inhibitory activities.

主 题 词：pyridine nitrile synthesis 

学科分类：081704[081704] 07[理学] 08[工学] 0817[工学-轻工类] 070303[070303] 0703[理学-化学类] 

核心收录：

D　O　I：10.1002/cjoc.201900494

馆 藏 号：203897984...