如果至多只能有3个胚胎培养超过原核期,长时间胚胎培养会减少第4天和第5天的种植率

作     者：Montag M. Ven K.V.D. Dorn C. Ven H.V.D. 朱磊 

作者机构：Department of Gynecological Endocrinology and Reproductive MedicineUniversity Clinics Bonn Sigmund-Freud-Str. 25 53105 Bonn Germany 

出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)

年 卷 期：2006年第2卷第4期

页      码：17-18页

摘      要：Objectives: To study the potential of embryo transfer after 3, 4 or 5 days of embryo culture under the German embryo protection law according to which only a maximum of three zygotes are allowed to be cultured for embryo transfer. Study design: In a prospective study, 273 patients with assisted reproductive treatment were randomly allocated for transfer on days 3, 4 or 5. Pregnancy and implantation rates were evaluated in regard to day of transfer and results were compared by Chi-square or ANOVA test. Results: Out of 234 transfer cycles, 79 were performed on day 3, 76 on day 4 and 79 on day 5. Pregnancy and implantation rates were 41.8%/27.1%for transfer on day 3, 27.6%/14.1%for day 4 transfer and 16.5%/8.8%for transfer on day 5. These results were significantly different for pregnancy rates on day 3 versus day 5 (P < 0.001) and for implantation rates on day 3 versus day 4 (P < 0.005) and day 3 versus day 5 (P < 0.001). Conclusions: These findings suggest that extended embryo culture is not beneficial when the option for embryo selection at later stages of development is not available.

主 题 词：胚胎培养 种植率 移植者 辅助生育 发育后期 方差分析 研究设计 

学科分类：1002[医学-临床医学类] 100211[100211] 10[医学] 

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