Very high baseline HIV viremia impairs efficacy of non-nucleoside reverse transcriptase inhibitor-based ART:a longterm observation in treatment-naïve patients

作     者：Shuai Chen Yang Han Xiao-Jing Song Yan-ling Li Ting Zhu Hong-Zhou Lu Xiao-Ping Tang Tong Zhang Min Zhao Yun He Sheng-Hua He Min Wang Yong-Zhen Li Shao-Biao Huang Yong Li Jing Liu Wei Cao Tai-Sheng Li 

作者机构：Department of Infectious DiseasesPeking Union Medical College HospitalChinese Academy of Medical SciencesNo.1 ShuaifuyuanWangfujing StreetBeijing 100730China 不详 

基　　金：The study was supported by the National Key Technologies R&D Program for the 13th Five-Year Plan(Grant No.2017ZX10202101) the National Key Technologies R&D Program for the 12th Five-Year Plan(Grant No.2012ZX10001003–001) the National Key Technologies R&D Program for the 11th Five-Year Plan(Grant No.2008ZX10001006–001) the CAMS Initiative for Innovative Medicine(CAMS-I2M:2017-I2M-1-014) 

出 版 物：《Infectious Diseases of Poverty》 (贫困所致传染病（英文）)

年 卷 期：2020年第9卷第3期

页      码：144-145页

摘      要：Background:It is not completely clear whether a very high pre-therapy viral load(≥500000 copies/ml)can impair the virological *** aim of this study was to examine the influence of very high baseline HIV-RNA levels on long-term virological responses under one type of ***:A retrospective study was performed based on data from two multicenter cohorts in China from January to November 2009,and from May 2013 to December *** HIV infected adults between 18 and 65 years old were recruited before receiving non-nucleoside reverse transcriptase inhibitor-based *** patients had baseline HIV-RNA levels over 500 copies/ml,good adherence,and were followed for at least 24 *** suppression was defined as the first HIV-RNA<50 copies/*** failure was defined as any of incomplete viral suppression(HIV-RNA≥200 copies/ml without virological suppression within 24 weeks of treatment)and viral rebound(confirmed HIV-RNA level≥50 copies/ml after virological suppression).Chi-square test,Kaplan–Meier analysis,Cox proportional hazards model and Logistic regression were used to compare virological response between each pretreated viral load ***:A total of 758 treatment-naïve HIV patients in China were *** follow-up time(IQR)was 144(108–276)*** week 48,rates of virological suppression in three groups(<100000,100000–500000 and≥500000 copies/ml)were 94.1,85.0,and 63.8%,respectively(P<0.001).Very high baseline HIV viremia over 500000 copies/ml were found to be associated with delayed virological suppression(≥500000 vs<100000,adjusted relative hazard=0.455,95%CI:0.32–0.65;P<0.001)as well as incomplete viral suppression(≥500000 vs<100000,adjusted odds ratio[aOR]=6.084,95%CI:2.761–13.407;P<0.001)and viral rebound(≥50000 vs<100000,aOR=3.671,95%CI:1.009–13.355,P=0.048).Conclusions:Very high levels of pre-treatment HIV-RNA were related with delayed efficacy of NNRTI-based ART and increased risk of treatment failure.

主 题 词：HIV Viral load Baseline RNA Antiretroviral therapy Treatment outcome Virologic response 

学科分类：1004[医学-公共卫生预防医学类] 100401[100401] 10[医学] 

核心收录：

D　O　I：10.1186/s40249-020-00700-8

馆 藏 号：203940145...