Heart-on-chips screening based on photonic crystals

作     者：Yixuan Shang Zhuoyue Chen Zhuohao Zhang Yuzhi Yang Yuanjin Zhao Yixuan Shang;Zhuoyue Chen;Zhuohao Zhang;Yuzhi Yang;Yuanjin Zhao

作者机构：Department of Clinical Medical EngineeringNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China State Key Laboratory of BioelectronicsSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China 

基　　金：This work was supported by the National Natural Science Foundation of China(Grants 61927805) the Natural Science Foundation of Jiangsu(Grant No.BE2018707) the Scientific Research Foundation of Nanjing University and Drum Tower Hospital 

出 版 物：《Bio-Design and Manufacturing》 (生物设计与制造（英文）)

年 卷 期：2020年第3卷第3期

页      码：266-280页

摘      要：Recently,organ-on-chips have become a fast-growing research field with the widespread development of microfluidic chips and synthetic materials in tissue *** to the existing cardiotoxicity of many cardiovascular drugs,heart-onchips which are promising to replace traditional animal models have been extensively researched and developed to mimic human organ functions in *** heart-on-chips mainly focus on cardiac mechanics,which is regarded as the central indicator of in vitro heart models and drug *** methods for the detection of myocardial mechanics have been demonstrated complex and inefficient in ***,photonic crystal materials with unique optical properties have attracted interests and have been introduced into the heart-on-chips,developing a visualized self-reporting system for cardiomyocytes activity *** this review,photonic crystal-based heart-on-chips for biosensing are introduced,as well as the fabricationmethods and design criteria of *** characterizations of the photonic crystal materials are classified into optical properties and structural properties,and their applications in cell culture and biosensing are further ***,several representative examples and developments of the integration of photonic crystal materials into microfluidic chips are described in ***,potentials and limitations are put forward to promote the development of the photonic crystal-based intelligent heart-on-chips.

主 题 词：Heart-on-chip Photonic crystal Self-reporting Biosensor Drug testing 

学科分类：08[工学] 080501[080501] 0805[工学-能源动力学] 080502[080502] 0803[工学-仪器类] 

核心收录：

D　O　I：10.1007/s42242-020-00073-9

馆 藏 号：203942044...