Self nano-emulsifying drug delivery system for Embelin:Design,characterization and in-vitro studies

作     者：Komal Parmar Jayvadan Patel Navin Sheth 

作者机构：Department of Pharmaceutical SciencesSaurashtra UniversityRajkotGujarat 360005India Nootan Pharmacy CollegeVisnagarGujarat 384315India 

出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)

年 卷 期：2015年第10卷第5期

页      码：396-404页

摘      要：CThe objective of the present study was to prepare solid self-nanoemulsifying drug delivery system(S-SNEDDS)containing Capryol-90 as oil phase for the delivery of Embelin,a poorly water soluble herbal active ***-Behnken experimental design was employed to optimise the formulation variables,X1(amount of oil;Capryol 90),X2(amount of surfactant;Acrysol EL 135)and X3(amount of co-surfactant;PEG 400).Systems were appraised for visual characteristics for self emulsifying time,globule size and drug *** liquid formulations were formulated into free flowing granules(S-SNEDDS)by adsorption on the porous materials like Aerosil 200 and Neusilin and thereby compressed into *** vitro dissolution studies of SNEDDS revealed increased in the dissolution rate of the ***-IR data revealed no physicochemical interaction between drug and *** state characterization of S-SNEDDS by DSC and Powder XRD confirmed reduction in drug crystallinity which further supports the results of dissolution *** analysis exhibited spherical ***,the accelerated stability studies for 6 months revealed that S-SNEDDS of Embelin are found to be stable without any significant change in physicochemical ***,the present studies demonstrated dissolution enhancement potential of porous carrier based S-SNEDDS for poorly water soluble herbal active ingredient,Embelin.

主 题 词：Embelin SNEDDS Dissolution enhancement Box-Behnken design Characterization 

学科分类：081704[081704] 07[理学] 070304[070304] 08[工学] 0817[工学-轻工类] 0703[理学-化学类] 

核心收录：

D　O　I：10.1016/j.ajps.2015.04.006

馆 藏 号：203969248...