A versatile Pt-Ce6 nanoplatform as catalase nanozyme and NIR-Ⅱ photothermal agent for enhanced PDT/PTT tumor therapy

作     者：Qing Chen Su He Fangjun Zhang Fengzhi Cui Jianhua Liu Man Wang Dongmei Wang Zhigang Jin Chunxia Li 陈晴;何素;张方军;崔凤至;刘建华;王曼;王冬梅;金志刚;李春霞

作者机构：Department of Life and ChemistryZhejiang Normal UniversityJinhua321004China Institute of Frontier and Interdisciplinarity Science and Institute of Molecular Sciences and EngineeringShandong UniversityQingdao266237China Department of Radiologythe Second Hospital of Jilin UniversityChangchun130041China 

基　　金：the National Natural Science Foundation of China(51872263 and 31970755) Zhejiang Provincial Natural Science Foundation(LZ19E020001 and LQ18B010002) 

出 版 物：《Science China Materials》 (中国科学（材料科学（英文版）)

年 卷 期：2021年第64卷第2期

页      码：510-530页

摘      要：The hypoxic nature of solid tumors has severely negative effects on oxygen-based photodynamic *** this study,we used porous Pt nanoparticles as a catalase(CAT)nanozyme,the second near-infrared(NIR-Ⅱ)region photothermal transition agents(PTAs),and carriers of photosensitizer chlorin e6(Ce6)to synthesize a composite nanosystem *** this system,Pt-Ce6 can continuously and stably decompose H2O2 into oxygen,thereby alleviating tumor hypoxia and improving the effect of photodynamic therapy(PDT).With 650 nm illumination,the reactive oxygen species(ROS)produced by Ce6 will decrease the mitochondrial membrane potential(MMP,ΔΨm)to release cytochrome c(Cyt-c)from the mitochondria into the cytoplasm,eventually leading to mitochondrial-mediated cellular apoptosis during the PDT *** addition,Pt-Ce6 has good photothermal stability and high photothermal conversion efficiency(52.62%)in the NIR-II *** U14 tumor-bearing mice,Pt-Ce6 completely suppressed tumor growth and recurrence under laser *** the nanocomposite shows excellent PDT/photothermal therapy(PTT)synergistic performance in vitro and in vivo.

主 题 词：hypoxia catalase photodynamic photothermal therapy cell apoptosis mechanisms 

学科分类：07[理学] 070205[070205] 08[工学] 080501[080501] 0805[工学-能源动力学] 080502[080502] 0702[理学-物理学类] 

核心收录：

D　O　I：10.1007/s40843-020-1431-5

馆 藏 号：203990605...