3D printing of PEEK–cHAp scaffold formedical bone implant

作     者：Bankole I.Oladapo SAbolfazl Zahedi Sikiru O.Ismail Francis T.Omigbodun Oluwole K.Bowoto Mattew A.Olawumi Musa A.Muhammad Bankole I.Oladapo;S.Abolfazl Zahedi;Sikiru O.Ismail;Francis T.Omigbodun;Oluwole K.Bowoto;Mattew A.Olawumi;Musa A.Muhammad

作者机构：School of Engineering and Sustainable DevelopmentDe Montfort UniversityLeicesterUK Centre for Engineering ResearchSchool of PhysicsEngineering and Computer ScienceUniversity of HertfordshireHatfieldUK Mechanical EngineeringLoughborough UniversityLoughboroughUK Faculty of EngineeringComputing and mediaDe Montfort UniversityLeicesterUK Faculty of EngineeringEnvironment and ComputingCoventry UniversityCoventryUK 

基　　金：We appreciate the funding/financial support received from the Higher Education Innovation Fund(HEIF)of De Montfort University Leicester UK under Research Project No.0043.06 

出 版 物：《Bio-Design and Manufacturing》 (生物设计与制造（英文）)

年 卷 期：2021年第4卷第1期

页      码：44-59页

摘      要：The major drawback associated with PEEK implants is their biologically inert surface,which caused unsatisfactory cellular response and poor adhesion between the implants and surrounding soft tissues against proper bone *** this study,polyetheretherketone(PEEK)was incorporated with calcium hydroxyapatite(cHAp)to fabricate a PEEK-cHAp biocomposite,using the fused deposition modeling(FDM)method and a surface treatment strategy to create microporous architectures onto the filaments of PEEK lattice ***,nanostructure and morphological tests of the PEEK-cHAp biocomposite were modeled and analyzed on the FDM-printed PEEK-cHAp biocomposite sample to evaluate its mechanical and thermal strengths as well as in vitro cytotoxicity via a scanning electron microscope(SEM).A technique was used innovatively to create and investigate the porous nanostructure of the PEEK with controlled pore size and distribution to promote cell penetration and biological integration of the PEEK-cHAp into the *** vivo tests demonstrated that the surface-treated micropores facilitated the adhesion of newly regenerated soft tissues to form tight implant-tissue interfacial bonding between the cHAp and *** results of the cell culture depicted that PEEK-cHAp exhibited better cell proliferation attachment spreading and higher alkaline phosphatase activity than PEEK *** islands formed on the PEEK-cHAp composite after immersion in simulated body fluid of Dulbecco’s modified Eagle medium(DMEM)for 14 days and grew continuously with more or extended *** microstructure treatment of the crystallinity of PEEK was comparatively and significantly different from the PEEK-cHAp sample,indicating a better treatment of *** in vitro results obtained from the PEEK-cHAp biocomposite material showed its biodegradability and performance suitability for bone *** study has potential applications in the field of biomedical engineering to strengthen the conceptual kn

主 题 词：3D printing PEEK-cHAp biocomposite Nanostructure Bone implant Composite morphing 

学科分类：08[工学] 080501[080501] 0805[工学-能源动力学] 080502[080502] 

核心收录：

D　O　I：10.1007/s42242-020-00098-0

馆 藏 号：203990981...