On-demand degradable magnetic resonance imaging nanoprobes

作     者：Wenbo Sun Zonghua Wang Jianhua Liu Chunhuan Jiang Weihua Chen Bin Yu Wei Wang Lehui Lu 孙文博;王宗花;刘建华;姜春环;陈伟华;于滨;王唯;逯乐慧

作者机构：College of Materials Science and EngineeringCollege of Chemistry and Chemical EngineeringShandong Sino-Japanese Center for Collaborative Research of Carbon NanomaterialsInstrumental Analysis Center of Qingdao UniversityQingdao UniversityQingdao 266071China State Key Laboratory of Electroanalytical ChemistryChangchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Department of RadiologySecond Hospital of Jilin UniversityChangchun 130041China 

基　　金：supported by the National Natural Science Foundation of China(21635007 and 21605137) the National Key Research and Development Program of China(2016YFA0203200) Natural Science Foundation of Shandong Province(2018GGX102030) Taishan Scholar Program of Shandong Province(ts201511027) K.C.Wong Education Foundation 

出 版 物：《Science Bulletin》 (科学通报（英文版）)

年 卷 期：2021年第66卷第7期

页      码：676-684,M0004页

摘      要：Theranostic nanoprobes can potentially integrate imaging and therapeutic capabilities into a single platform,offering a new personalized cancer diagnostic ***,there is a growing concern that their clinical application is not safe,particularly due to metal-containing elements,such as the gadolinium used in magnetic resonance imaging(MRI).We demonstrate for the first time that the photothermal melting of the DNA duplex helix was a reliable and versatile strategy that enables the on-demand degradation of the gadolinium-containing MRI reporter gene from polydopamine(PDA)-based theranostic *** combination of chemotherapy(doxorubicin)and photothermal therapy,which leads to the enhanced anti-tumor *** vivo MRI tracking reveals that renal filtration was able to rapidly clear the free gadolinium-containing MRI reporter from the mice *** results in a decrease in the long-term toxic effect of theranostic MRI *** findings may pave the way to address toxicity issues of the theranostic nanoprobes.

主 题 词：MRI reporter DNA-based Photothermal melting On-demand degradation Theranostic nanoprobes 

学科分类：0831[工学-公安技术类] 1004[医学-公共卫生预防医学类] 07[理学] 070205[070205] 08[工学] 080501[080501] 0805[工学-能源动力学] 0702[理学-物理学类] 10[医学] 

核心收录：

D　O　I：10.1016/j.scib.2020.10.020

馆 藏 号：203994021...