Sequence Similarity Analysis of Non-Self CTL Epitopes and Mouse Proteins Using Sequence Alignment

作     者：CAI Ruikun CHENG Xi MA Chuang ZHOU Yanhong 

作者机构：Hubei Bioinformatics and Molecular Imaging Key LaboratoryHuazhong University of Science and Technology Wuhan 430074Hubei China 

基　　金：Supported by the National Natural Science Foundation of China (90608020, 30971642) the Program for New Century Excellent Talents in University (NCET-060651) the National Platform Project of China (2005DKA64001) Ministry of Education of China (20050487037) the Natural Science Foundation of Hubei Province (2009CDA161) 

出 版 物：《Wuhan University Journal of Natural Sciences》 (武汉大学学报（自然科学英文版）)

年 卷 期：2011年第16卷第1期

页      码：69-72页

摘      要：This research analyzed amino acid sequence similarity between non-self T cell epitopes recognized by mouse antibodies and mouse proteins. Using sequence alignment,we found that only 8 of 1 108 epitopes are highly similar to mouse protein sequences. The result shows that non-self T cell epitopes are not similar or have little similarity to mouse protein sequences. Furthermore,reviewing the related literature,we also found that the eight epitopes would trigger immune responses in some particular environment,which are ignored by T cells in normal condition. The result suggests that no or low-similarity peptide vaccines can reduce the chance of collateral cross-reactions and enhance the antigen-specific immune response to vaccine.

主 题 词：T cell epitopes mouse proteome vaccine design bioinformatics 

学科分类：0831[工学-公安技术类] 0710[理学-生物科学类] 0711[理学-心理学类] 1007[医学-药学类] 100705[100705] 07[理学] 08[工学] 071005[071005] 10[医学] 

D　O　I：10.1007/s11859-011-0713-3

馆 藏 号：203995260...