Visualization of α_1-adrenergic receptors with phenylpiperazine-based fluorescent probes

作     者：Yuxing Lin Wenhua Li Qinying Yu Xinyang Zhou Wei Zhang Lupei Du Minyong Li 

作者机构：Key Laboratory of Chemical Biology (Ministry of Education) Department of Medicinal Chemistry School of Pharmacy Shandong University 

基　　金：supported by the Fok Ying Tong Education Foundation (122036) the Program of New Century Excellent Talents in University (NCET-11-0306) the Major Project of Science and Technology of Shandong Province (2015ZDJS04001) the Shandong Natural Science Foundation (JQ201019) the Independent Innovation Foundation of Shandong University (2010JQ005) 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2016年第59卷第5期

页      码：624-628页

摘      要：Several novel fluorescent probes targeting α_1-adrenergic receptors were well designed and synthesized by conjugating phenylpiperazine pharmacophore with coumarin and fluorescein fluorophores. These compounds showed suitable fluorescence property, high receptor affinity, and low cytotoxicity. Moreover, the cell imaging results displayed that these probes can be effective tools for the real-time detection of ligand-receptor interactions, as well as the visualization and location of α_1-adrenergic receptors in living cells.

主 题 词：α1-adrenergic receptors fluorescent probes high affinity fluorescent imaging 

学科分类：081704[081704] 07[理学] 08[工学] 0817[工学-轻工类] 070302[070302] 0703[理学-化学类] 

核心收录：

D　O　I：10.1007/s11426-015-5503-x

馆 藏 号：203997712...