摘要：Objective To establish a rat model of chronic atrophic gastritis and explore the factors inducing *** In accordance with repeated orthogonal design of L8(27), 60% alcohol and 20mmol/L sodium deoxycholate (served as factor A), 0.05%-0.1% ammonia water (factor B), 0.05% indomethacin (factor C) were given, alone or in combination, to rats in three experiments for 3 months, 6 months or 9 months respectively. Then the rats were dissected, and their pathologic changes of the gastric mucosa were *** Typical signs of chronic atrophic gastritis (CAG) were found in all rats which were treated with factor A, B, C alone or in combination for 6 or 9 months. No significant difference of pathologic changes of gastric mucosa was found between the rats treated for 6 months and those for 9 months. No obvious CAG signs were found in the rats treated with factor A, B, C for 3 *** Sixty percent of alcohol, 20mmol/L sodium deoxycholate, 0.05%-0.1% ammonia water and 0.05% indomethacin given to Sprague-Dawley rats for 6 months can successfully establish the animal model of CAG. Prolongation of the model-establishment time is not able to further facilitate the atrophy of gastric mucosa.

摘要：目的　建立鼠慢性萎缩性胃炎 (CAG)动物模型并探讨致萎缩因素。方法　应用① 6 0 %酒精和 2 0mmol/L去氧胆酸钠 (A因素 ) ;② 0 .0 5 %～ 0 .1%氨水 (B因素 ) ;③ 0 .0 5 %吲哚美辛 (C因素 )按有重复的L8(2 7)正交设计对SD大鼠分三批进行制模刺激 ,三批刺激时间分别为 3个月、6个月和 9个月。实验到期后取出全胃 ,观察大鼠胃黏膜大体观及各项萎缩指标。结果　应用A、B、C三因素 (单因素或多因素 )刺激 6个月或 9个月均出现典型的胃窦萎缩性胃炎征象 ,制模成功率达 10 0 % ,且能维持形态稳定 1个月以上。结论　应用 6 0 %酒精和 2 0mmol/L去氧胆酸钠 ,0 .0 5 %～ 0 .1%氨水 ,0 .0 5 %吲哚美辛对SD大鼠刺激 6个月可成功地建立CAG模型 。