摘要：Bioceramics have attracted extensive attention for bone defect repair due to their excellent bioactivity and ***,challenges remain in matching the rate between bioceramic degradation and new bone formation,necessitating a deeper understanding of their degradation *** this study,density functional theory(DFT)calculations was employed to explore the structural and electronic characteristics of silicate *** findings reveal a linear correlation between the maximum isosurface value of the valence band maximum(VBM_(Fmax))and the degradability of silicate *** correlation was subsequently validated through degradation ***,the investigation on phosphate bioceramics demonstrates the potential of this descriptor in predicting the degradability of a broader range of *** discovery offers valuable insights into the degradation mechanism of bioceramics and holds promise for accelerating the design and development of bioceramics with controllable degradation.

摘要：研究生物材料所产生的化学信号与细胞行为之间的作用关系,对于高性能组织工程材料的设计与制备具有重要的指导意义.本工作中,采用化学共沉淀法成功地合成了含钼(Mo)的硅酸盐(MS)生物活性陶瓷粉体,并探究其降解产生的活性离子化学信号对肌腱-骨相关细胞(肌腱干/祖细胞(TSPCs)和骨髓间充质干细胞(BMSCs))的调控作用.所合成的MS生物陶瓷颗粒大小均一,其降解后的浸提液中含有Mo、钙(Ca)、硅(Si)三种生物活性离子.特定浓度范围的MS浸提液可以同时促进TSPCs和BMSCs的增殖和迁移活性.更重要的是,MS浸提液可以同时刺激TSPCs和BMSCs的特异性分化,说明MS生物陶瓷释放的化学离子所构建的微环境,能够同时协调TSPCs和BMSCs的细胞行为.因此,MS生物陶瓷有望作为一种有效的“生物活性因子”用于肌腱-骨损伤修复.