摘要：本控制器针对串联式混合动力汽车进行设计,根据整车工作状态及工作模式对辅助动力单元进行控制,以调节辅助动力单元工作状态,协调混合动力电动汽车能量分配。整车采用串联式混合动力结构,由蓄电池组和发电机组提供能量,以三相异步电机构成驱动系统。本控制器实现了基于TMS320F2812的辅助动力单元控制器的设计。采用了由发电机组的放电电流和发动机转速构成的双闭环控制结构,在实际应用中使辅助动力单元的能量输出达到了良好的控制效果。

摘要：In vaccine development,broadly or cross-type neutralizing antibodies(bnAbs or cnAbs)are frequently targeted to enhance *** immunodominant antibodies could help fine-tune vaccine immunogenicity and augment the precision of immunization ***,the methodologies to capitalize on the attributes of bnAbs in vaccine design have not been clearly *** this study,we discovered a cross-type neutralizing monoclonal antibody,13H5,against human papillomavirus 6(HPV6)and *** nAb exhibited a marked preference for HPV6,demonstrating superior binding activity to virus-like particles(VLPs)and significantly higher prevalence in anti-HPV6 human serum as compared to HPV11 antiserum(90%vs.31%).Through co-crystal structural analysis of the HPV6 L1 pentamer:13H5 complex,we delineated the epitope as spanning four segments of amino acids(Phe42-Ala47,Gly172-Asp173,Glu255-Val275,and Val337-Tyr351)on the L1 surface *** interaction analysis and site-directed mutagenesis revealed that the Ser341 residue in the HPV6 HI loop plays a critical role in the interaction between 13H5 and *** Ser341 with alanine,which is the residue type present in HPV11 L1,almost completely abolished binding activity to *** swapping amino acids in the HPV11 HI loop with corresponding residues in HPV6 L1(Ser341,Thr338,and Thr339),we engineered chimeric HPV11-6HI ***,the chimeric HPV11-6HI VLPs shifted the high immunodominance of 13H5 from HPV6 to the engineered VLPs and yielded comparable neutralization titers for both HPV6 and HPV11 in mice and non-human *** approach paves the way for the design of broadly protective vaccines from antibodies within the main immunization reservoir.

摘要：文昌针对机修车间3 t电炉烟尘污染严重及危害职工身体健康情况,提出了顶部集烟罩捕集烟尘+袋式除尘器为烟尘捕集净化处理的设计方案。

摘要：为使不能行手术切除的晚期贲门癌和食管癌病人进食,设计了剔除肿瘤近侧食管粘膜癌灶旷置后重建食管术。本术式避免了不剔除粘膜而单纯切断食管封闭近肿瘤断端后形成潴留性“囊肿”的可能。本组10例术后效果优于行单纯剖胸探查术、胃或空肠造瘘术、食管腔内置管术及食管胃底转流术者。