摘要：There has been unprecedented progress in the development of biomedical nanotechnology and nanoma- terials over the past few decades, and nanoparticle-based drug delivery systems （DDSs） have great potential for clin- ical applications. Among these, magnetic drug delivery systems （MDDSs） based on magnetic nanoparticles （MNPs） are attracting increasing attention owing to their favor- able biocompatibility and excellent multifunctional loading capability. MDDSs primarily have a solid core of super paramagnetic maghemite （y-Fe^03） or magnetite （Fe304） nanoparticles ranging in size from 10 to 100nm. Their surface can be functionalized by organic and/or inorganic modification. Further conjugation with targeting ligands, drug loading, and MNP assembly can provide complex magnetic delivery systems with improved targeting efficacy and reduced toxicity. Owing to their sensitive response to external magnetic fields, MNPs and their assemblies have been developed as novel smart delivery systems. In this review, we first summarize the basic physicochemical and magnetic properties of desirable MDDSs that fulfill the requirements for specific clinical applications. Secondly, we discuss the surface modifications and functionalization issues that arise when designing elaborate MDDSs for future clinical uses. Finally, we highlight recent progress in the design and fabrication of MNPs, magnetic assemblies, and magnetic microbnbbles and liposomes as MDDSs for cancer diagnosis and therapy. Recently, researchers have focused on enhanced targeting efficacy and theranostics by applying step-by-step sequential treatment, and by magnetically mod- ulating dosing regimens, which are the current challenges for clinical applications.

摘要：以台湾南部屏东地区的黄缘萤栖地为研究对象,调查栖地水质环境并探讨水土保持工程(景观护岸)对黄缘萤之影响。调查结果显示:该地区的水质环境相当适合黄缘萤的生存,黄缘萤繁殖的两个高峰期分别为11月与6月,且黄缘萤求偶的高峰期约在日落后1h。土堤护岸黄缘萤数量为景观护岸的三倍以上,造成此差异的原因主要为景观护岸的设计并未考虑黄缘萤的成长及繁衍过程,所以造成影响。因此水土保持工程的设计与施作,必须考虑当地生物习性才能降低对生物栖地的破坏,以免影响生态保育。

摘要：长江自青海发源,穿行于西藏、四川、云南的高山峡谷,水色金黄、古产沙金,故在此段又称金沙江。这里流急坎陡、水势惊险、落差巨大,是中国水能资源的富矿。2010年10月开工、2021年6月首批机组投产发电的白鹤滩水电站,就坐落在其下游段,被称为“当今世界在建规模最大、技术难度最高的水电工程”。

摘要：SBS改性沥青在我国道路施工中应用广泛,随着研究的不断深入,复合改性沥青逐渐成为主要提高沥青性能的手段之一。为探究碳纳米管对SBS改性沥青复合改性后的高温性能,首先借助高速剪切仪,采用熔融共混法制备出不同掺量的碳纳米管/SBS复合改性沥青,通过布氏旋转黏度试验、多应力蠕变试验,研究不同掺量的碳纳米管对SBS改性沥青的高温性能影响。结果表明:碳纳米管的加入能够提升SBS改性沥青的黏度、高温流变性能和高温抗车辙变形能力。

摘要：随着地下空间的开发,必要情况下施工建设需要在相对寒冷的环境下进行,此时基坑建设可能会出现越冬情况,为研究越冬基坑的支护结构水平位移及桩侧冻胀力,运用三维快速拉格朗日数值分析软件(FLAC3D),在悬臂桩支护形式下,对不同桩体直径及插入比的越冬深基坑支护结构桩侧冻胀力及水平位移进行分析。分析得出,在冻结状态下,悬臂桩支护基坑水平位移峰值是常温时的4.5倍,桩侧冻胀力峰值增加了2倍,冻胀作用对基坑变形和受力影响非常显著;随着桩径增加,桩侧冻胀力随之迅速增加而水平位移峰值不断减小;桩体水平位移及桩侧冻胀力受插入比的变化影响很小。该成果可为以悬臂桩为主的排桩支护形式在越冬深基坑工程中的设计、施工提供理论参考。