摘要：随着数字技术的发展,数字化与信息化建设已经成为社会各领域重点实施的内容,也是社会发展的必然要求。在水利工程的设计过程中,会涉及大量的数据信息存储与交换,这就需要对数据进行高效和安全管理,要想让水利工程设计的质量得到有效保障,加强对信息化系统的建设就显得尤为重要。

摘要：为解决水质处理提升工程中生物砾石滤床技术在应用过程中关于滤床规模参数的确定以及不同规模、不同边界条件的滤床对不同区域条件、不同污染程度河道的污染处理效果模拟预测等问题,以汉中某水系为例,基于QUAL2k水质模型,结合室内小型概化实验监测成果,模拟研究不同工况下砾石滤床对河道水质净化效果。结果表明,夏季200 m长的滤床对NH_(4)^(+)-N、PO_(4)^(3-)-P、COD的去除率最高分别为51.5%、54.3%、54.1%,可将控制断面PO_(4)^(3-)-P、COD提升至《地表水环境质量标准》(GB 3838-2002)Ⅲ类水标准,将NH_(4)^(+)-N提升至Ⅳ类水标准;冬季400 m的滤床对NH_(4)^(+)-N、PO_(4)^(3-)-P、COD的去除率最高分别为68.6%、57.5%、51.1%,实现COD达到Ⅲ类水、PO_(4)^(3-)-P接近Ⅳ类水的水质目标。

摘要：近年来,随着中俄关系的持续升温,两国在各领域的交流与合作逐渐增多。“档案外交”作为一种独特的外交手段,在提升国家软实力、展现国家良好形象、提高本国档案学界的国际地位等方面发挥了不可替代的作用,中俄档案外交为中国与其他国家树立了良好的外交典范。本文首先分析了开展“档案外交”的基础,其次从实践的角度梳理出中俄档案对外交流活动,进一步归纳出中俄“档案外交”开展的形式、功能及影响,最后探讨了新时代下加强“档案外交”的实现路径。未来,档案外交应加强顶层设计使档案外交国策化、拓展档案合作的范围,扩大档案外交的主体等,以迎来档案外交的全新发展,为维护国家利益做出更大的贡献。

摘要：In the present study, a chitosan-coated calcium phosphate nanoparticle（CS/CaP/siRNA NP） was developed to deliver si RNA for treatment of cervical cancer. The CS/CaP/siRNA NPs were prepared by the nano-precipitation method. The resulted NPs had a uniform spherical morphology with a size of ～194 nm and a zeta potential of ～＋27 mV. In vitro experiments demonstrated that these NPs could efficiently deliver si EGFR into Hela cells and significantly down-regulate the EGFR expression level, which was probably associated with enhanced cell adhesion of chitosan, leading to extended residence time of cell internalization. Then the internalized CS/CaP/siRNA NPs exhibited pH-responsive disassembly of NPs, resulting in the enhanced release of si RNA and rapid lysosomal escape into cytoplasm. Moreover, in vivo anticancer results showed that the CS/CaP/siRNA NPs had significant inhibitory effects on tumor growth after intratumoral injection in Hela tumor xenografted nude mice, accompanying with no obvious changes of body weight during the whole experimental period. All these results indicated that the CS/CaP/siRNA NPs would have great potential to deliver si RNA for the treatment of cervical cancer via mucosal administration.