摘要：To improve the efficiency and correctness of the review,we aimed to continuously improve the review strategy of parenteral nutrition(PN)prescriptions.A calculation formula(CF)and an electronic prescription reviewing system(EPRS)were designed to improve *** improvements were divided into three periods:pre-improvement,improvement period-1(CF was used),and improvement period-2(EPRS-CF was used).A retrospective analysis for inpatients receiving PN support from January to May 2019,June to October 2019,and June to October 2020,was conducted to evaluate the defect and efficiency of the PN prescription *** with the pre-improvement period,the efficiency of the PN prescription review in the CF period was *** addition,in the EPRS-CF period,the efficiency and correctness of the PN prescription review were remarkably increased(P<0.01).Moreover,through the verification of PN prescriptions in the EPRS-CF period,pharmacists improved the efficiency and correctness of the PN prescription ***,the PDCA(plan-do-check-act)circulation method could help improve the PN reviewing process in the future.

摘要：目的探讨临床药师在新生儿重症监护室开展肠外营养临床药学服务的工作及切入点。方法结合新生儿生长发育的特点,临床药师自主设计新生儿肠外营养管理计算公式,指导并审核肠外营养医嘱,对新生儿进行肠外营养监护。结果临床药师以新生儿肠外营养管理公式为工作切入点,开展新生儿肠外临床药学服务工作。结论临床药师在新生儿重症监护室的肠外营养临床药学服务中具有重要作用,为开展其他药学服务工作打好基础。

摘要：目的:研究复方鸦胆子油脂质体的处方筛选及制备工艺。方法:采用气相色谱法测定脂质体包封率。以脂质体包封率为主要指标,对制备工艺中可能影响脂质体性质的工艺参数和处方因素进行单因素考察和正交设计,优化制备工艺。用不同冻干保护剂进行冷冻干燥,以筛选合适的保护剂。测定Zeta电位、粒径大小及分布。结果:采用乙醇注入法制备复方鸦胆子油脂质体;最佳制备工艺为磷脂浓度为1.5%,磷脂胆固醇质量比为5∶1,油水两相体积比为1∶10,甘露醇∶蔗糖∶磷脂质量比为1∶1∶1,水相介质为蒸馏水,温度为50℃,搅拌速度为30 rpm。最佳处方制备的平均包封率为91.9%,Zeta电位为-32.1 mV,平均粒径为170.3 nm。结论:该实验制备的复方鸦胆子油脂质体具有包分率高、稳定性好、表面带负电等特点,为进一步研究复方鸦胆子油脂质体奠定了基础。