摘要：目的改良小鼠皮肤光老化动物模型的建立方法,为临床防治皮肤光老化打下基础。方法设计制作一种构建小鼠皮肤光老化动物模型的装置,利用装置中紫外线(UVA 315~400nm;UVB 280~315nm)照射ICR小鼠,3次/周,共12周,累计照射剂量:UVA为151.20J/cm2,UVB为22.68J/cm^2;观察照射部位皮肤的临床表现、组织病理及超微结构的改变情况,测定皮肤中羟脯氨酸含量。结果与正常对照组小鼠皮肤比较,模型组皮肤出现粗糙增厚、弹性丧失、粗深皱纹、毛细血管扩张、脱屑及皮革样外观;组织病理可见表皮不规则增厚,真皮胶原纤维变性,断裂减少,排列紊乱,分布不均;超微结构显示胶原纤维排列紊乱,分布不均,周期性横纹不清,横断面胶原纤维直径增大,粗细不等;皮肤中羟脯氨酸含量显著减少(P<0.01)。提示造模成功。结论利用改良的自制造模装置建立ICR小鼠皮肤光老化动物模型是一种简便易行、经济实用、可复性强的方法。

摘要：特应性皮炎(AD)是一种常见的慢性复发性炎症性皮肤病,其发病率逐年上升。当前,由于其诊断标准在我国皮肤科医生中普及率低,导致大量AD患者被漏诊。该现象的产生与我国皮肤科临床教学中的教材、教学大纲、皮肤科试卷,以及临床实习的多个环节设计不合理有密切关系。本文通过分析目前我国AD临床教学中存在的问题,提出相应的解决方案。

摘要：Background: Ablative skin resurfacing with carbon dioxide (CO2) and erbium:YA G lasers is still considered the gold standard for treating rhytides, photodamag e, and acne scars. However, the prolonged downtime and undesired concomitant eff ects that are involved have sent dermatologists looking for less invasive nonabl ative laser techniques to rejuvenate skin. Objective: To combine cold-air cool ing with single-pass CO2 laser skin resurfacing to generate as much benefit as possible while minimizing the spectrum of adverse effects. Study Design: The ef ficacy of single-pass CO2 laser skin resurfacing on perioral and periorbital w rinkles was examined prospectively during a 6- month follow-up period. In a s ide-by-side comparison, the influence of simultaneous cold-air cooling on concomitant effects, pain tolerance, therapeutic success, and patient satisfacti on was also studied. Eight patients with perioral and/or periorbital wrinkles un derwent the procedure. During laser treatment, only the right half of each facew as cooled using a cold-air system. Results: Six months after treatment, a mild improvement of the wrinkles was observed in all cases. The use of cold-air co oling did not have any impact on the longterm results, although in a direct comp arison between sides, it was observed that