摘要：目的:优选超临界CO2流体萃取法萃取丹葶肺心颗粒中挥发油的工艺条件。方法:以萃取压力、萃取温度、萃取时间3个因素为主要影响因素,以鱼腥草素得率、鱼腥草挥发油得率、枳壳挥发油得率、总评归一值(OD)为评价指标进行Box-Behnken设计试验,考察最佳萃取工艺。结果:优化的最佳工艺条件为:萃取压力27.5 MPa,萃取温度58℃,萃取时间105 min,此时鱼腥草素、鱼腥草挥发油、枳壳挥发油得率分别为0.061%、1.973%,0.752%;对最佳工艺进行验证,结果实测平均值与模型预测值非常接近,表明该模型较可靠。结论:采用Box-Behnken设计方法科学、合理、可行;超临界萃取效率高,稳定性好,在中药复方挥发油的提取方面有相当大的发展潜力。

摘要：目的:优化丹参总酚酸的微波真空干燥工艺。方法:以丹参总酚酸中有效成分丹酚酸B的含量为指标,采用三因素三水平Box-Behnken设计法,考察了微波真空干燥前浸膏密度、微波功率、干燥时间等影响因素。结果:最佳工艺经过验证,确定其工艺参数为:将浸膏浓缩至密度为1.29 g·m L-1的稠膏,微波功率为585 W,干燥22分钟;对最佳工艺进行验证,结果实测平均值与模型预测值非常接近,表明该模型较可靠。结论:微波真空干燥具有干燥时间短、耗能低、特别适合热敏性成分的干燥等优点,值得在中药物料的干燥工序中推广应用。

摘要：目的:研究白芷香豆素微囊的制备工艺,并考察其体外释药特性。方法:以包封率、载药量为指标,采用复凝聚法制备白芷香豆素微囊,用Doehlert设计法对白芷香豆素的制备工艺进行优化,用UV法测定微囊在20h内溶出的量并作释放度考察曲线,且采用电镜对其形态与粒径进行考察。结果:白芷香豆素微囊的囊材囊心比、搅拌速度及体系的pH值对微囊的包封率与载药量均有显著影响,当囊材囊心比为4.3∶1、搅拌速度为355 r·min-1、pH值5.0时,制得的白芷香豆素微囊圆整光滑,无粘连,粒径均匀,包封率可高达77.74%,载药量为23.03%,囊径在200μm以下,且有一定的缓释作用。结论:复凝聚法制备白芷香豆素微囊工艺简单、可靠,产品稳定性好。

摘要：A neutron-TPC （nTPC） is being developed for use as a fast neutron spectrometer in the fields of nuclear physics, nuclear reactor operation monitoring, and thermo-nuclear fusion plasma diagnostics. An nTPC prototype based on a GEM-TPC （Time Projection Chamber with Gas Electron Multiplier amplification） has been assembled and tested using argon-hydrocarbon mixture as the working gas. By measuring the energy deposition of the recoil proton in the sensitive volume and the angle of the proton track, the incident neutron energy can be deduced. A Monte Carlo simulation was carried out to analyze the parameters affecting the energy resolution of the nTPC, and gave an optimized resolution under ideal conditions. An alpha particle experiment was performed to verify its feasibility, and to characterize its performance, including energy resolution and spatial resolution. Based on the experimental measurement and analysis, the energy resolution （FW-HM） of the nTPC prototype is predicted to be better than 3.2% for 5 MeV incident neutrons, meeting the performance requirement （FWHM〈5%） for the nTPC prototype.