摘要：本文用均匀设计方法筛选了黄芪多糖脂质体的处方并考查了脂质体的几种制备方法，采用筛选的处方和熔融法制备了十几批黄芪多糖脂质体，制备的黄芪多糖脂质体体系稳定，由化学稳定性预测黄芪多糖脂质体20℃贮存期为1．44年；测定了黄芪多糖脂质体的粒度分布，90％以上粒子粒径1μm以下，40℃保温3个月粒子粒径不变．在此基础上进一步研究证明了黄芪多糖脂质体比黄芪多糖普通制剂和空白脂质体具有更加显著的免疫增强效果．

摘要：Six factors and 10 levels of each factor were selected by using the (uniform design method( with the aid of the computer for preparing APS liposomes. The optimal procedure for preparing APS liposomes was established and it can suit the large scale production in a pharmaceutical factory. The shelf-life of APS liposomes at 20℃ is 1.46 years. Diameters of the vesicles ( > 90% ) in APS liposomes are less than 1 μm, and the system is stable. At 40℃ the diameters of vesicles were not changed in three months. Pharmacological experiments revealed that APS liposomes exerted a strong immunoenhancement in mice. Studies in this paper established a foundation for the production and the clinical application of APS liposomes.