摘要：目的:基于新型冠状病毒(SARS-CoV-2)全病毒或Spike蛋白作为免疫原可能存在的无关抗原表位干扰,筛选鉴定优势保护性抗原表位,构建候选多价表位疫苗。方法:以免疫信息学确定诱导主要中和抗体、激活细胞免疫应答的细胞保护性抗原表位,以Raptor X、trRosetta预测蛋白疫苗的二级、三级结构,并对候选蛋白疫苗进行二硫键的设计及对接分析,以C-ImmSim服务器模拟预测分析多表位疫苗的免疫原性和免疫应答。结果:实验筛选了Spike蛋白免疫原性强的B细胞表位,具有高保守性和人群覆盖度广的IFN-γ、IL-4阳性的Th表位及CTL表位,计算模拟验证了疫苗的免疫应答特性。结论:信息学分析结果初步显示候选表位疫苗具有良好的平衡体液免疫和细胞免疫应答能力。

摘要：The photoreduction of greenhouse gas CO_(2) using photocatalytic technologies not only benefits en-vironmental remediation but also facilitates the production of raw materials for ***-er,the efficiency of CO_(2) photoreduction remains generally low due to the challenging activation of CO_(2) and the limited light absorption and separation of *** engineering of catalysts rep-resents a pivotal strategy to enhance the photocatalytic activity for CO_(2),with most research on met-al oxide catalysts focusing on the creation of anionic *** exploration of metal vacancies and their effects,however,is still *** this study,we prepared an In2O3 catalyst with indium vacancies(VIn)through defect engineering for CO_(2) *** and theo-retical calculations results demonstrate that VIn not only facilitate light absorption and charge sepa-ration in the catalyst but also enhance CO_(2) adsorption and reduce the energy barrier for the for-mation of the key intermediate*COOH during CO_(2) *** metal vacancy engineering,the activity of the catalyst was 7.4 times,reaching an outstanding rate of 841.32μmol g(-1)h^(-1).This work unveils the mechanism of metal vacancies in CO_(2) photoreduction and provides theoretical guidance for the development of novel CO_(2) photoreduction catalysts.

摘要：文章介绍了国内自2010年以来建成的四型有代表意义的非自航大型绞吸挖泥船和国外最大的两艘非自航绞吸挖泥船,可以看到国内自主研制能力已经步入国际领先行列。集成船舶设计通用原理和绞吸挖泥船专业疏浚设备开发技术,用图形的方式表示了该船型设计的主要方面。扼要介绍了"新海旭"的总布置、航区、动力配置、疏浚输送系统和钢桩台车定位系统等,并对大型绞吸挖泥船的作业航区、动力配置方案和疏浚输送系统生产能力等进行了探讨和分析。论文提出的绞吸挖泥船设计原理和对"新海旭"的技术状态介绍可供开发大型绞吸挖泥船参考。