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摘要：目的观察实验性自身免疫性脑脊髓炎（EAE）模型大鼠脑组织中硫化氢（H2S）动态变化，探讨H2S与多发性硬化（MS）的关系。方法按随机区组设计方法将SD大鼠分成对照组及模型组，每组78只。模型组制备EAE模型，对照组用生理盐水代替诱导乳剂，余措施相同。采用HE染色、尼氏染色观察2组大鼠脑组织病理变化；比较不同时间点（建模后5、10、15、20、25、30、35、40、45、50、55、60d和65d）2组大鼠平均临床评分；采用比色法检测各时间点H2S和丙二醛（MDA）水平。结果（1）HE和尼氏染色显示模型组中可见明显的炎性细胞浸润现象及血管袖套形成，对照组未发现明显改变。（2）模型组于建模后第20天及第50天出现2次发病高峰，临床评分分别为（4．0±0．55）分和（3．5±0．25）分；对照组的评分为0分。（3）模型组大鼠各时间点脑组织中H2S表达量随着发病呈逐渐下降趋势，从第10天开始低于对照组，差异有统计学意义（P〈0．05）。相反，模型组大鼠各时间点脑组织中MDA呈逐渐增加趋势，从第10天开始高于对照组，差异有统计学意义（P〈0.05）。对照组大鼠H2S和MDA水平无明显变化。（4）模型组大鼠脑组织中H2S水平的变化与临床评分、MDA水平呈负相关（r=0．960，P=0．000；r：=-0．920，P=0．000）；临床症状评分和MDA水平呈正相关（r=0．910,P=0．000）。结论H2S在EAE模型中表达明显降低，在MS中的作用机制有待进一步研究。

摘要：With the prompt development in intellectualization nowadays, the smart materials with multifunctionality or multi-responsiveness are highly expected. But it is a big challenge to integrate the different actuating units into a single system in a synergy pattern. Herein, we put forward a new strategy to develop the polyurethane networks which can present shape-memory effect and self-healing effect in independent way as well as simultaneous acting mode. To realize this goal, poly(tetremethylene ether) glycol was chosen as the soft segment to ensure the polymer chains a good mobility, and disulfide bond as the dynamic covalent bond was embedded in the backbone of polyurethane to endow it with desirable self-healing capacity under mild condition. Moreover, a rational control of the architecture of the networks by adjusting the content of disulfide bond and the degree of cross-linking, a broad glass transition temperature(T_g) was achieved, which enabled the network a versatile shape-memory effect, covering from dual-, triple-so far as to quadrupleshape memory effect. More importantly, the shape recovery and healing process can be realized simultaneously because of the highly matched actuating condition in this system.