摘要：Ob.ectives: Antiretroviral therapy (ART) has b.en associated with lipodystrophy in children. We evaluated changes in various anthropometric measurements for the assessment of lipodystrophy and assessed whether there was an association with use of protease inhib.tors (PI), non-PI containing ART and/or stavudine (d4T). Methods: Eighty-five HIV-infected children attending the HIV clinic at Great Ormond Street Hospital (GOSH) were included. The average follow-up was 8.4 months (range 3 - 12 months). b.dy fat redistrib.tion was assessed b. anthropometric measurements including skinfold thickness and circumferences of upper and lower limb.. Measurements were converted to age- and sex-adjusted z-scores through development stages including pub.rty. Results: Sixty children had taken ART;37 received PI-containing;38 received d4T;25 had never b.en treated. In the studied population, clinically important changes with decreases in b.ceps (b.F), sub.capular skinfolds and total b.dy fat (4SFT) over period of 12 months were ob.erved. Some increase was noticed in triceps skinfolds (TSF). Limb. circumferences remained at the same level. Further we looked at 4 months b.sis changes in anthropometric measurements stratified b. b.seline ART. Generally z-scores of anthropometric measurements were lower in therapy naive children when compared to ART groups. PI-b.sed ART regimens resulted in significant increases in b.F with a trend towards increases in TSF, suprailiac and 4SFT. Mid-arm and thigh circumferences were higher in PI compared to naive group. Similarly, significant changes in b.F z-scores were associated with d4T use. Increases were seen in TSF and mid-arm circumference and decreases were ob.erved in sub.capular skinfolds and calf circumference z-scores. Conclusions: b.dy fat redistrib.tion in HIV-infected children with sub.clinical lipodystrophy could b. detected b. anthropometric measurements, particularly when PI or d4T is included in ART. Over time, changes with increase in a