摘要：Obje.tive. To e.aluate.the.possible.re.ationship be.we.n pre.clampsia and poly morphisms in the.main ge.e. involve. in folate.homocyste.ne.me.abolism. Study d e.ign: Case.control study: 43 patie.ts with pre.clampsia and 122 controls witho ut pre.nancy complications. Laboratory studie.: tHcy and othe. amino acids, fola te.and vitamin B12 and polymorphisms: 677C >T and 1298A >C(MTHFR); 699C >T, 844i ns68 and 1080C >T (CBS); 2756A >G (MTR); and 66G >A, IVS1+766G >A and IVS1+754 A >C (MTRR). Re.ults: Plasma tHcy and folate.value. we.e.significantly highe. (P = 0.004 and P = 0.019), while.Me./tHcy ratios we.e.lowe. (P C polymorphism (MTHFR) with the.ratio Me./tHcy (P = 0.014); the.699 C >T polymorphism (CBS) with the.ratio tHcy/ΣAA (P = 0.013); the.2756A >G polym orphism (MTR) with tHcy (P = 0.034); and the.IVS1+766G >A polymorphism (MTRR) w ith hype.homocyste.ne.ia (P = 0.012). Conclusion: An association be.we.n the.pol ymorphisms analyse. and pre.clampsia could not be.de.onstrate..