摘要：To expand the study on the structures and biological activities of the anthracyclines anticancer drugs and reduce their toxic side effects,the new anthraquinone derivatives,9‑pyridylanthrahydrazone(9‑PAH)and 9,10‑bispyridylanthrahydrazone(9,10‑PAH)were designed and *** 9‑PAH and 9,10‑PAH as promising anticancer ligands,their respective copper complexes,namely[Cu(L1)Cl_(2)]Cl(1)and{[Cu_(4)(μ_(2)‑Cl)_(3)Cl_(4)(9,10‑PAH)_(2)(DMSO)_(2)]Cl_(2)}_(n)(2),were subsequently synthesized,where the new ligand L1 is formed by coupling two 9‑PAH ligands in the coordination *** chemical and crystal structures of 1 and 2 were elucidated by IR,MS,elemental analysis,and single‑crystal X‑ray *** 1 forms a mononuclear structure.L1 coordinates with Cu through its three N atoms,together with two Cl atoms,to form a five‑coordinated square pyramidal *** 2 constitutes a polymeric structure,wherein each structural unit centrosymmetrically encompasses two five‑coordinated binuclear copper complexes(Cu1,Cu2)of 9,10‑PAH,with similar square pyramidal geometry.A chlorine atom(Cl_(2)),located at the symmetry center,bridges Cu1 and Cu1A to connect the two binuclear copper ***,the two five‑coordinated Cu2 atoms symmetrically bridge the adjacent structural units via one coordinated Cl atom,respectively,thus forming a 1D chain‑like polymeric *** vitro anticancer activity assessments revealed that 1 and 2 showed significant cytotoxicity even higher than ***,the IC_(50)values of 2 against HeLa‑229 and SK‑OV‑3 cancer cell lines were determined to be(5.92±0.32)μmol·L^(-1)and(6.48±0.39)μmol·L^(-1),respectively.2 could also block the proliferation of HeLa‑229 cells in S phase and significantly induce cell *** addition,fluorescence quenching competition experiments suggested that 2 might interact with DNA by an intercalative binding mode,offering insights into its underlying anticancer ***:

摘要：以产品风格意象为造型设计切入点,展开目标人群风格意象与产品造型特征匹配与优选研究下的产品造型改良设计,实现企业产品造型形象的一致性延续。以拖挂式房车为设计对象,针对目标人群对其风格意象的感性评价,运用调查问卷、KJ法、聚类分析等方法归纳评价资料与量化数据,确立企业房车造型的风格意象,并以部件类目提取企业房车的造型基因特征;选取市场上拖挂式房车为样本,以同样的部件类目展开造型基因特征的提取,以此建立企业房车风格意象与样本造型基因特征的匹配与优选。通过建立房车造型设计要素组合矩阵及相应的量化处理,得出复合风格意象值较高的房车造型设计要素组合,以此展开拖挂式房车造型的设计与测评,实现企业在延续自身风格意象下优化房车造型的目的。

摘要：立足“产品设计方法学”“理论+实践”的课程特征与具备“设计+”的交叉研究属性,探索以课程理论方法为基,实施知识传授,以思政教育专题实践为用,实施价值塑造和能力培养的专业教育与思政教育的融合模式。经过对课程教学内容的分析整理、思政教育专题实践的归纳构建、课堂教学的组织实施与考核评价等的研究,系统构建了“理论方法+思政教育专题实践”的课程思政教学策略,以期实现知识传授、价值塑造和能力培养的多元统一,达到专业育人与思政育人的双重目标,并以此为其他专业课程融入思政教育提供建设思路,助力高校课程思政的全面建设工作。