摘要：Background:Surgical site infections are the most frequent type of preventable hospital acquired infections with a serious and undesirable outcome of surgery associated with increase morbidity,mortality rate,hospital stay,readmission and excess *** site infection prevention is one of the most important challenge in delivering optimal nursing *** suggest that the nurses’practices of surgical site infection prevention is not well ***,there is clearly paucity of information,in Africa including the study ***:The aim of this study was to assess surgical site infection prevention practices and associated factors among nurses working in government hospitals of Harari Regional State and Dire Dawa City Administration,Eastern Ethiopia from March 01 to 28,*** and Materials:An institutional based cross-sectional study design was employed for a total of 515 *** random sampling method was used to select study *** were collected using pretested structured self-administered questionnaire supplemented by *** were checked,coded,entered and cleaned using Epi-data version 3.1 and exported to SPSS version 20 for *** and multivariate analysis were undertaken and P values less than 0.05 at 95%confidence interval were considered as statistically ***:The overall self-reported level of SSI prevention practice was found to be 40.8%(95%CI:36.9%,45.4%).Nurses with BSc and above[Adjusted odds ratio(AOR)=2.52,95%CI(1.14,5.54)],trained on infection prevention[AOR=2.22,95%CI(1.29,3.82)],good knowledge[AOR=2.21,95%CI(1.32,3.71)],good attitude[AOR=5.11,95%CI(3.05,8.57)],got supply of personal protective equipment[AOR=2.57,95%CI(1.46,4.49)],had management support[AOR=3.41,95%CI(1.90,6.12)],experience of 5 to 10 years[AOR=5.38,95%CI(2.82,10.27)]and≥11 years[AOR=3.48,95%CI(1.47,8.25)],were found to be statistically and positively associated with nurses SSI prevention ***