摘要：Refractory alloys such as tungsten and molybdenum based alloys with high strength,thermal/electrical conductivity,low coefficient of thermal expansion and excellent creep resistances are highly desirable for applications in nuclear facilities,critical components in aerospace and defense ***,the serious embrittlement limits the engineering usability of some refractory alloys.A lot of research results indicate that the performances of refractory alloys are closely related to the physical/chemical status,such as the interface dimension,interface type,interface composition of their grain boundaries(GBs),phase boundaries(PBs)and other interface *** paper reviewed the recent progress of simulations and experiments on interface design strategies that achieve high performance refractory *** strategies include GB interface purifying/strengthening,PB interface strengthening and PB/GB synergistic *** details are provided on the design/fabrication strategy such as GB interface controlling,PB interface controlling and synergistic control of multi-scaled *** corresponding performances such as the mechanical property,thermal conductivity,thermal load resistance,thermal stability,irradiation resistance,and oxidation resistance are reviewed in the aspect to the effect of *** addition,the relationships between these interfaces and material properties are ***,future developments and potential new research directions for refractory alloys are proposed.