摘要：A novel series of pyrido[ 1,2-e]purin-4（3H）-one derivatives containing polar substituents on 5＇-position were designed and prepared as potential PDE5 inhibitors. This paper reports the synthetic routes, 1H-NMR data, and the PDE5 inhibitory activities of the target compounds. The polar piperazinyl group contained （on 5＇-position） compound, 3B2, showed the highest activity among the tested derivatives but less potency than sildenafil 1.

摘要：Soil phosphomonoesterase plays a critical role in controlling phosphorus(P) cycling for crop nutrition,especially in P-deficient soils.A 6-year field experiment was conducted to evaluate soil phosphomonoesterase activities,kinetics and thermodynamics during rice growth stages after consistent swine manure application,to understand the impacts of swine manure amendment rates on soil chemical and enzymatic properties,and to investigate the correlations between soil enzymatic and chemical *** experiment was set out in a randomized complete block design with three replicates and five treatments including three swine manure rates(26,39,and 52 kg P ha^(-1),representing low,middle,and high application rates,respectively) and two controls(no-fertilizer and superphosphate at 26 kg P ha^(-1)).The results indicated that the grain yield and soil chemical properties were significantly improved with the application of P-based swine manure from 0 to 39 kg P ha^(-1);however,the differences between the 39(M_(39)) and 52 kg P ha^(-1) treatments(M_(52)) were not *** enzymatic property analysis indicated that acid phosphomonoesterase was the predominant phosphomonoesterase in the tested *** M_(39) and M_(52) treatments had relatively high initial velocity(V_0),maximal velocity(V_(max)),and activation grade(lgN_a) but low Michaelis constant(K_m),temperature coefficient(Q_(10)),activation energy(E_a),and activation enthalpy(ΔH),implying that the M_(39) and M_(52) treatments could stimulate the enzyme-catalyzed reactions more easily than all other *** correlation analysis showed that the distribution of soil phosphomonoesterase activities mainly followed the distributions of total C and total *** on these results,39 kg P ha^(-1) could be recommended as the most appropriate rate of swine manure amendment.

摘要：根据国内现有跨声速风洞实验条件,采用仿真设计和传统设计相结合的方法,设计了可以进行舵面跨声速气动弹性特性研究的舵面模型两自由度柔性支撑实验装置。该实验装置主要由弹性元件、配重和舵面部分组成。调节弹性元件圆轴的直径和长度可以改变支撑的弯曲刚度和扭转刚度,在配重盘上增减配重可以改变系统的质量特性。通过对实验装置的结构动力建模,对不同配重状态下的装置进行了模态计算和分析,计算结果显示实验装置的前两阶模态分别为舵面沉浮模态和舵面扭转模态,结果表明实验装置的这种结构形式能够满足舵面相对刚性的假设,可以用于研究舵面弯扭耦合颤振问题。同时用PK(Panovsky-Kielb)法对舵面的风洞实验设计参考点的颤振临界速度进行了估算,计算的颤振结果满足现有风洞实验条件。

摘要：A kind of pseudo Gray code presentation of test patterns based on accumulation generators is presented and a low power test scheme is proposed to test computational function modules with contiguous subspace in very large scale integration （VLSI）, especially in digital signal processors （DSP）. If test patterns from accumulators for the modules are encoded in the pseudo Gray code presentation, the switching activities of the modules are reduced, and the decrease of the test power consumption is resulted in. Results of experimentation based on FPGA show that the test approach can reduce dynamic power consumption by an average of 17.40% for 8-bit ripple carry adder consisting of 3-2 counters. Then implementation of the low power test in hardware is exploited. Because of the reuse of adders, introduction of additional XOR logic gates is avoided successfully. The design minimizes additional hardware overhead for test and needs no adjustment of circuit structure. The low power test can detect any combinational stuck-at fault within the basic building block without any degradation of original circuit performance.

摘要：基于加法器的测试生成,提出了直接实现形式的细粒度流水线延迟最小均方自适应滤波器的一种可测性设计的测试方案。在测试模式下,该设计通过滤波器组成模块的分层隔离及由寄存器转化成的扫描链提高了可测性;通过复用部分寄存器和加法器避免或最小化了额外的测试硬件开销。该方法能在真速下高效地侦测到滤波器基本组成单元内的任意固定型组合失效,且不会降低电路的原有性能。

摘要：本文发展了一种提高跨音压气机效率的优化设计方法。该方法由快速叶片造型和网格生成、三维NS方程求解器和优化方法三部分组成。以绝热效率为设计目标,只选择两个参数-最大弯度和最大厚度相对位置沿叶高的分布为优化参数,成功设计了一个跨音单转子压气机。在此基础上,进一步考察了叶片端布周向弯曲对跨音单转子压气机性能的影响。

摘要：针对高压直流开关电源变压器绝缘易被击穿和输入并联输出串联电源拓扑输出电压纹波大、精度低的问题,提出了改变变压器绕组布局结构的分段式绕制方法和一种数字化错相控制策略。首先,详细给出了分段式变压器的绕制结构和设计方法;其次,基于所建立的占空比与输出电压的数学模型,给出了错相控制策略中最小纹波因数下的占空比设计原则,并对纹波因数进行了定量分析;最后,绕制了分段式高频高压变压器样品,研制了36kV/10A电子束轰击炉电源的样机。实验结果表明:变压器分段式绕制方法降低了副边绕组的层间电场强度,进而可降低变压器绝缘等级,防止变压器绝缘击穿;所提出的错相控制策略可把输出电压纹波由23.2%降低到3.5%。总体来说,所提出的方法和策略提高了36kV电子束轰击炉高压直流开关电源的功率密度和稳定性。

摘要：本文研究与分析了叶型中弧线的最大弯度位置对跨音速压气机叶片气动性能的影响。采取了注重流动机理的优化方法,对本文算例的风扇叶片进行了优化,改进后所得的叶片的效率比原设计有了较大的提高。

摘要：结合某高速公路体外预应力试验桥的设计,利用桥梁分析专业软件MIDAS/Civil对该桥的转向块区域力学性能进行了空间仿真分析,研究了该关键区域的应力分布、受力特点以及传力路径;根据混凝土材料本构关系和屈服准则提出了利用应力差值分析屈服区域特性的研究手段.得出转向块结构竖向压应力主要分布在肋部的转向管道以上部分;竖向拉应力主要分布在转向肋与底板交界外缘处以及转向管道之间区域,建议加宽转向管道间距,以减小该区域的应力集中现象.根据仿真分析结果,对实际工程的设计和施工提出了一些切实可行的建议,研究结论可供类似工程参考.

摘要：To reduce the fuel consumption and emissions and also enhance the molten aluminum quality, a mathematical model with user-developed melting model and burning capacity model, were established according to the features of melting process of regenerative aluminum melting furnaces. Based on validating results by heat balance test for an aluminum melting furnace, CFD （computational fluid dynamics） technique, in association with statistical experimental design were used to optimize the melting process of the aluminum melting furnace. Four important factors influencing the melting time, such as horizontal angle between burners, height-to-radius ratio, natural gas mass flow and air preheated temperature, were identified by PLACKETT-BURMAN design. A steepest descent method was undertaken to determine the optimal regions of these factors. Response surface methodology with BOX-BEHNKEN design was adopted to further investigate the mutual interactions between these variables on RSD （relative standard deviation） of aluminum temperature, RSD of furnace temperature and melting time. Multiple-response optimization by desirability function approach was used to determine the optimum melting process parameters. The results indicate that the interaction between the height-to-radius ratio and horizontal angle between burners affects the response variables significantly. The predicted results show that the minimum RSD of aluminum temperature （12.13%）, RSD of furnace temperature （18.50%） and melting time （3.9 h） could be obtained under the optimum conditions of horizontal angle between burners as 64°, height-to-radius ratio as 0.3, natural gas mass flow as 599 m3/h, and air preheated temperature as 639 ℃. These predicted values were further verified by validation experiments. The excellent correlation between the predicted and experimental values confirms the validity and practicability of this statistical optimum strategy.