摘要：Introduction and research overview Recently,increasing need for organ transplantation and lack of donated organs have led to the rapid development of new technologies for artificial organ *** the era of burgeoning breakthroughs around 3D bioprinting technologies,the personalization of organs and medicine is an ongoing nice vision[1–5].As one of the leading laboratories in the interdisciplinary field of materials,manufacturing and bioengineering,the Biofabrication(3D Bioprinting)Research Laboratory at Sichuan University has been engaging in the research on customized regenerativemedicine since 2012.

摘要：At present,the clinical reconstruction of the auricle usually adopts the strategy of taking autologous costal *** method has great trauma to patients,poor plasticity and inaccurate ***-dimensional(3D)printing technology has made a great breakthrough in the clinical application of orthopedic *** study explored the combination of 3D printing and tissue engineering to precisely reconstruct the ***,a polylactic acid(PLA)polymer scaffold with a precisely customized patient appearance was fabricated,and then auricle cartilage fragments were loaded into the 3D-printed porous PLA scaffold to promote auricle *** vitro,gelatin methacrylamide(GelMA)hydrogels loaded with different sizes of rabbit ear cartilage fragments were studied to assess the regenerative activity of various autologous cartilage *** vivo,rat ear cartilage fragments were placed in an accurately designed porous PLA polymer ear scaffold to promote auricle *** results indicated that the chondrocytes in the cartilage fragments could maintain the morphological phenotype in *** three months of implantation observation,it was conducive to promoting the subsequent regeneration of cartilage in *** autologous cartilage fragments combined with 3D printing technology show promising potential in auricle reconstruction.

摘要：The bone regenerative scaffold with the tailored degradation rate matching with the growth rate of the new bone is essential for adolescent bone *** satisfy these requirement,we proposed bone tissue scaffolds with controlled degradation rate using osteoinductive materials(Ca-P bioceramics),which is expected to present a controllable biodegradation rate for patients who need bone *** properties,porosity,compressive strength and degradation properties of the scaffolds were studied.3D printed Ca-P scaffold(3DS),gas foaming Ca-P scaffold(FS)and autogenous bone(AB)were used in vivo for personalized beagle skull defect *** results indicated that the 3DS was highly vascularized and well combined with surrounding *** showed obvious newly formed bone *** showed the best repair effect,but it was found that AB scaffolds were partially absorbed and *** study indicated that the 3D printed Ca-P bioceramics with tailored biodegradation rate is a promising candidate for personalized skull bone tissue reconstruction.

摘要：提出一种三转动自由度冗余驱动飞行模拟器。在3-RRR球面并联机构的基础上,通过球面平行四边形机构的引入而实现冗余驱动,从而克服电机驱动相对于液压驱动功率相对较小的缺点。将一般3-RRR球面并联机构的参数进行变化,从而设计出体积相对较小的运动机构。利用空间球面解析理论建立了各支链的方向余弦,在方向余弦建立的基础上给出机构的雅可比矩阵。利用支链夹角不变原理建立了机构的约束方程,进行了运动学反解分析。考虑球面平行四边形冗余驱动支链的干涉情况,根据向量叉积定理计算得出了输入转角范围,并通过一种数值正解算法计算得到机构给定输入参数的工作空间。分析结果表明,在给定特定结构参数的情况下,所提出的飞行模拟器具有转角大的优点,远远大于传统的Stewart机构,从而为飞行模拟器的实际应用提供一种新的选择。

摘要：根据面向复杂机械产品开发的分布式智能决策的设计要求,构建了一种基于多Agent 技术的复杂机械产品开发系统模型。该模型对系统知识进行了分类和有效表述,开发了多个 Agent 功能模块,通过黑板机制完成不同 Agent 之间的信息通讯和交互,通过工作流管理实现系统分布式协同工作。研究实例表明,该系统能够有效地分解复杂产品开发的工作流任务,降低复杂产品开发的复杂性和提高开发效率。

摘要：针对微型机电系统(MEMS)设计所存在的多学科交叉、周期长等问题,以自顶向下的三级建模法为基础,结合多学科优化设计法,提出了基于三级建模的微型机电系统多学科优化设计法。该方法既保持了三级建模法设计效率高的优点,又能够很好地解决MEMS设计中多学科耦合的问题,比较适合复杂MEMS的设计任务,可以进一步提高设计效率。该方法在微加速度计设计中的应用,证明了该方法在MEMS设计中的有效性。

摘要：针对航天器中大型球冠蜂窝防热层结构自动灌注问题,设计了一种3自由度混联灌注机器人,并建立灌注机器人的机构模型.该混联机器人结构紧凑、驱动简单、占地面积小,末端灌注装置始终垂直于球冠面移动,有利于蜂窝结构的灌注;采用多机器人操作模式,提高了灌注效率.通过建立运动学约束方程,分析了机构的运动学反解,同时建立了机构的速度雅可比矩阵,在此基础上,利用一种高效的数值正解算法分析了运动学正解,并通过对位置正解的分析得出灌注机器人的整个工作空间,并基于速度雅可比矩阵对机构的灵巧性和奇异性进行分析.结果表明灌注机器人能够实现对蜂窝结构的精确定位,且工作空间能够达到整个球冠面,满足蜂窝防热层结构的灌注要求.

摘要：基于电力在能源体系中的核心地位和推动能源低碳转型的关键作用,创新提出系统评估全球各区域各国电力发展成效的全球电力发展指数,并根据能源可持续发展理念构建“两级四维”指标体系进行指数测算,从供应保障、消费服务、绿色低碳、技术创新等4个维度反映各区域、各国家电力发展水平。采用五分位法对基础数据进行了标准化处理,并运用主客观相结合的方法对一级指标和二级指标权重设计。最后对全球六大洲100个国家开展了电力发展指数和各维度专项指数测算,并进行了相应排序和分析,旨在为决策制定者、投资者、电力行业从业者及关注电力行业发展的相关人士提供参考。

摘要：采用非自耗真空电弧炉熔炼新锆合金,并对成分设计、熔炼、铸态锆合金组织与硬度等进行了研究。结果表明:该工艺能够准确得到预期的化学成分,且Nb均匀分布在锆合金内;随着铌含量的增加,铸锭的硬度增大,组织变得细小,铌具有细化组织的作用。

摘要：为解决山东金玺泰矿业有限公司干堆后微细粒尾矿的处理问题,设计三段深度浓缩工艺,并根据工艺特点对传统旋流器进料体、柱段和锥角等进行优化改进。通过单因素(压力P)试验对比改进后旋流器的浓缩能力和净化能力。试验结果表明:改进后旋流器Smax100/PU-K和Smax75/PU-WY的浓缩性能和净化能力有了明显的提升,工业机型SPWK-650现场试验指标达到充填浓度≥68%,回水浓度≤2%,满足现场生产要求。