摘要：Background:Traditional tissue engineering methods to fabricate urinary tract patch have some drawbacks such as compromised cell viability and uneven cell distribution within *** this study,we combined three-dimensional(3D)bioprinting and tissue engineering method to form a tissue-engineered urinary tract patch,which could be employed for the application on Beagles urinary tract defect mode to verify its effectiveness on urinary tract ***:Human adipose-derived stem cells(hADSCs)were dropped into smooth muscle differentiation medium to generate induced microtissues(ID-MTs),flow cytometry was utilized to detect the positive percentage for CD44,CD105,CD45,and CD34 of *** of vascular endothelial growth factor A(VEGFA)and tumor necrosis factor-stimulated gene-6(TSG-6)in hADSCs and MTs were identified by Western *** the ID-MTs were employed for 3D *** bioprinted structure was encapsulated by transplantation into the subcutaneous tissue of nude mice for 1 *** retrieval of the encapsulated structure,hematoxylin and eosin and Masson’s trichrome staining were performed to demonstrate the morphology and reveal collagen and smooth muscle fibers,integral optical density(IOD)and area of interest were calculated for further semiquantitative *** double staining of CD31 andα-smooth muscle actin(α-SMA)were used to reveal vascularization of the encapsulated *** was performed to evaluate the expression of interleukin-2(IL-2),α-SMA,and smoothelin of the MTs in the implanted ***,the encapsulated structure was seeded with human urothelial *** staining of cytokeratins AE1/AE3 was applied to inspect the morphology of seeded encapsulated ***:The semi-quantitative assay showed that the relative protein expression of VEGFA was 0.355±0.038 in the hADSCs vs.0.649±0.150 in the MTs(t=3.291,P=0.030),while TSG-6 expression was 0.492±

摘要：Twenty-three 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-(N-cycloproyl-N-substituted-amino)-2-propanols were designed and synthesized on the basis of the active site of lanosterol 14α-demethylase. In vitro antifungal activities showed that some of the title compounds had higher antifungal activity and broader antifungal spectrum than fluconazole.

摘要：近期,动物主题珠宝展《美丽生灵》(Beautiful Creatures)在美国自然历史博物馆(AMERICAN MUSEUM OF NATURAL HISTORY)展出。期间,展览展出120件动物元素珠宝作品,呈现了19世纪中叶迄今著名珠宝商与当代设计师的精妙创意。它揭示了世界上最具标志性的珠宝动物群以及佩戴它们的独特女性的秘密。珠宝作为一个体量如此“微小”的物件,与自然、历史和人类文化曾经产生或者正在产生怎么样的同频共振呢?

摘要：Based on the active site of lanosterol 14α-demethylase of azole antifungal agents,sixteen 1-（1H-1,2,4-triazole-1-yl）- 2-（2,4- difluorophenyl）-3-（N-n-butyl-N-1-substitutedbenzyl-4-methylene-1H-1,2,3-triazole）-2-propanols have been designed,synthesized and evaluated as antifungal *** of preliminary antifungal tests against eight human pathogenic fungi in vitro showed that some of the compounds exhibited excellent activities with broad spectrum.

摘要：Seeking for innovative structures with higher mechanical performance is a continuous target in railway vehicle crashworthiness *** the present study,three types of hexagonal reinforced honeycomb-like structures were developed and analyzed subjected to out-of-plane compression,namely triangular honeycomb(TH),double honeycomb(DH)and full inside honeycomb(FH).Theoretical formulas of average force and specific energy absorption(SEA)were constructed based on the energy minimization *** validate,corresponding numerical simulations were carried out by explicit finite element *** agreement has been observed between *** results show that all these honeycomb-like structures maintain the same collapsed stages as conventional honeycomb;cell reinforcement can significantly promote the performance,both in the average force and SEA;full inside honeycomb performs better than the general,triangular and double schemes in average force;meanwhile,its SEA is close to that of double scheme;toroidal surface can dissipate higher plastic energy,so more toroidal surfaces should be considered in design of thin-walled *** achievements pave a way for designing high-performance cellular energy absorption devices.

摘要：A series of 1-（1H-1,2,4-triazole-1-yl）-2-（2,4-difluoropheny1）-3-（N-isoproy1-N-substituted-amino）-2-propanols have been designed and synthesized on the basis of the active site of lanosterol 14a-demethylase （CYP51）. Their structures were confirmed by MS and ^1H NMR. In vitro antifungal activities of these synthesized compounds were evaluated against eight human pathogenic fungi. The results showed that all title compounds exhibited activity against fungi tested to some extent. Compounds 3c, 3d, 7a, 7b and 7e exhibited more potent antifungal activities against nearly all fungi tested except AspergiUus fumigatus than fluconazole. ？2009 Qiu Ye Wu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All fights reserved.

摘要：与其他行业不同,可持续理念对于当代首饰来说,并非单纯一种因环境影响的被动选择,纵观很多不论是经典首饰作品还是艺术家、设计师的最新创作,都能看出“可持续”为首饰在材料和技艺上的发展起到了不期而会的驱动作用。

摘要：不论我们对2020年设想了多少个"意料之中",但还是收到了一个"意料之外"的开场。一场新型冠状病毒疫情猝不及防地席卷了社会的各行各业,当然也波及到了文化艺术领域。居家禁足、展览延期、机构关闭、工厂停工等因素使不论文化艺术机构还是艺术家个体都需要重新思考自己的境遇,以及面对这"猝不及防"境遇所反应的"力所能及"。

摘要：2020年11月28日,《年·鉴2020》上海大学美术学院首饰工作室师生展正式开幕。开幕仪式上汇集了来自全国各地的艺术家、学者及首饰设计专业的学习者。"年鉴"师生年度展是以2016年"海上十年"研究生教学回顾展为开端,每年一"鉴",至2020年已是第五届。

摘要：随着北京市功能区定位和规划的完成,大力发展文化创意产业不仅仅是经济结构调整的需要,而且是发挥城市功能的内在需要。为了厘清北京发展文化创意产业的优势、劣势、机遇和威胁,借助SWOT分析方法对其拥有的丰富的历史文化资源、充足的资金资源和人才资源以及面临的机遇和威胁进行了深度梳理。分析表明,北京市发展文化创意产业的优势和机遇显著,同时也存在高房价等引致的劣势以及区域竞合等方面的威胁。