摘要：The estrogen receptor is a target for therapeutic agents for hormone replacement in menopausal women,osteoporosis, reproductive cancers such as breast cancer,uterine cancer and prostate cancer.1,4-Dihydrothieno[3＇,2＇：5,6]thiopyrano[4,3- c]pyrazole-3-carboxylic amide derivatives were designed,synthesized and biological evaluated as potential estrogen receptor antagonists.

摘要：在国家大力实施乡村振兴战略的背景下,艺术乡建作为一种创新的乡村振兴方式引起了社会学界和艺术学界的广泛关注。自2018年起,艺术乡建成为研究热点。聚焦中国知网学术数据库中2012—2023年关于艺术乡建领域的近300篇文献,通过共现分析和聚类分析的模式,揭示了艺术乡村建设在乡村振兴中的关键作用。目前,艺术乡村建设研究的主题可分为10个类别,高频关键词包括公共艺术、人类学、乡村主体性、介入策略、在地性、乡村文化振兴、乡村公共空间等。战略坐标图表明,“艺术乡村建设与文化复兴”和“艺术乡村建设的空间重构及地域性研究”将是未来艺术乡建研究的重点。最后,提出了对未来艺术乡建研究的建议,包括共同体与社会关系的再平衡、利益相关诉求的再探讨、艺术乡建实践成果的再评价、艺术乡建实践方法的微观求证、数字化赋能艺术乡建研究。

摘要：Bromination is used as a strategy to improve biological activity in medicinal *** order to study on the structure-activity relationships of the novel acetylcholinesterase inhibitors with 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one scaffold,based on our previous work and molecular modeling,a series of novel 3-aryl-6-（bromoarylrnethyl）-7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives were designed by molecular docking,synthesized and characterized by mass spectra,infrared spectra,proton NMR and elemental *** study of AChE inhibitory activity was carried out using the Ellman colorimetric assay with huperzine-A as the positive *** of all target compounds exhibited more than 45%inhibition at 10μmol/*** preliminary structureactivity relationship was the bromine atoms and the hydroxyl group at the phenyl ring at the C6 position of the parent nucleus played significant roles in the AChE inhibitory activity of the target compounds.

摘要：在职业学校职业技术教育信息技术类课程教学中,重视学生思维能力的培养,引导学生掌握思考问题的方法,提升学生的实践操作能力,教师务必要开展教学设计。一个理论与实践操作相结合的高质量教学设计应该包括八个基本部分,教学进程分为六个步骤,教学设计体现双主教学结构,注重合作探究,落实学科核心素养目标。在了解学情的基础上,运用案例分析法,利用信息化教学手段和教学资源,结合基于MATLAB的GUI图形界面设计教学内容,提出了以“简易计算器设计”为案例的教学设计。

摘要：1 成吉思汗雕塑群简介全球最大的青铜艺术工程成吉思汗雕塑群，是纪念成吉思汗称汗800周年，弘扬蒙古文化而创意策划的主题性与纪念性的巨型青铜雕塑艺术工程。2006年8月8日，在内蒙古鄂尔多斯市康巴什新区成吉思汗广场成功落成。

摘要：This article aims to explore the intersection of law and literature,analyzing their connections and ***,the article introduces the definitions and basic characteristics of law and literature,emphasizing their similarities and ***,the article discusses how literary works involve legal issues and how law becomes the subject and background of literary *** addition,the article studies the interaction between law and literature,exploring the impact of novels on legal practice,and how legal texts are rewritten and interpreted in literary ***,the article summarizes the relationship between law and literature and offers some prospects and reflections.

摘要：在艺术活动中,欣赏者的接受才是艺术活动的主体,艺术生命的存在、延续和拓展都是靠接受者来完成和实现的。接受者作为审美对象的欣赏者,在音乐审美接受过程中通过参与并构建音乐形象来表达在音乐审美过程中接受的意义。

摘要：A series ofN-（furan-2-ylmethyl）-lH-indole-3-carboxamide derivatives（6a--6p） was designed and synthe- sized for developing novel indole scaffolds as anticancer agents targeting the epidemal growth factor receptor （EGFR）, and the cytotoxic activities of the target compounds were evaluated against three EGFR high-expressed cancer cell lines[human lung adenocarcinoma cell line（A549）, Henrietta Lacks strain of cancer cell line（HeLa） and human colorectal cancer cell line（SW480）], one EGFR low-expressed cell line（human liver cancer cell line, HepG2） and one human liver normal cell line（HL7702） using 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyl tetrazolium bromide （MTT） assay, Some target compounds exhibited potent anficancer activities against A549, HeLa, SW480 and weak activities on HepG2, which signifies that the target compounds are likely to be EGFR inhibitors as expected. And they showed weak cytotoxic effects on HL7702, which implies the target compounds are probably to be of low toxicity against normal cells. Among them, the target compound 1-ethyl-N-（fttran-2-ylmethyl）-5-{2-{ [2-（2-methoxy- phenoxy）ethyl]amino}-2-oxoethoxy}-2-methyl-1H-indole-3-carboxamide（6p） with 2-{[2-（2-methoxyphenoxy）ethyl]- amino}-2-oxoethoxy group at the C5 position of the N-（furan-2-ylmethyl）-lH-indole-3-carboxamide scaffold exhibited the most potent anticancer activity. Also the binding interaction of the target compound 6p with EGFR was explored by molecular docking. Conclusively, the novel indole scaffold may be beneficial to investigate new anticancer agents for targeting the EGFR.

摘要：为了匹配不同类型和规格的工程数字投影机的投影球形幕,提出了设计通用型投影变焦鱼眼镜头的基本方法。首先,基于投影鱼眼镜头自身特性和通用性特点,确定了目标系统采用的光学结构类型;通过优选配置二组元变焦核初始条件参数,对补偿组的位移曲线进行了线性改造,从而使两条凸轮曲线可同步构造为标准螺旋线。之后,通过合理控制前固定组球差及后固定组焦距,使变焦过程中的像面保持稳定。设计结果表明,光学系统采用二运动组元机械补偿式正组变倍负组补偿结构,在变焦过程中可以保持全视场角160°和孔径F#为2基本不变。通过合理控制过程参量,可以使系统适配光学引擎中棱镜的有效光学厚度为16.5～26mm,满足1LCD、3LCD和1DMD常见技术类型、16～24cm(0.63～0.95in)芯片尺寸及16∶9和4∶3两种芯片长宽比的数字工程投影机使用,像面位移量控制在±0.03mm以内。该设计可以满足投影鱼眼镜头的常规投影及通用性要求,结构简单,工艺性强。

摘要：设计作为人类创造技术人工物的实践活动形式,在技术哲学的“经验转向”中引导众多研究者将目光聚集到对技术复杂性与丰富性经验的充分描述上。技术设计成为打开技术黑箱的重要线索,是分析和解决技术异化的重要视角。然而除了对技术设计作“工具性”的理解之外,其本身还具有丰富的本体性内涵。在具体的实践发展中,技术设计也正在面临着诸如“人类有限理性”“多元价值冲突”等内部与外部的挑战,导致技术设计在参与技术发展过程中出现了严重失范现象。从技术设计的内部结构出发,深入剖析技术设计失范的具体表现及其根源,进而从伦理、民主等多个层面探讨恢复技术设计正当性的策略,旨在确保正确的发展理念能够贯穿于人—设计—技术—世界的应有逻辑链条之中,发挥其引领作用。