摘要：正交性与空间填充性是计算机试验设计的两个重要性质.本文提出通用的旋转方法用以构造一类新的正交空间填充设计.这类设计既具有正交性,又有理想的空间填充性.此外,本文提出的构造方法简单易行,且生成的设计具有灵活的试验次数和水平数.生成的设计既可以是对称的,也可以是非对称的.相关理论支撑科学严谨.本文构造并给出许多新的具有理想的空间填充性的正交设计.旋转矩阵和差阵在构造中起到重要的作用.

摘要：标准体系建设对于推动职业教育高质量发展具有重要意义,专业教学标准在标准体系中发挥着承上启下的关键作用。新版职业教育专业教学标准贯彻落实《教育强国建设规划纲要(2024—2035年)》精神,体现了需求导向、中高本一体化、要素自洽的主要特征:从社会逻辑看,新版标准注重需求导向,服务区域发展、产业发展和助力高水平对外开放的布局体系落地实施;从体系逻辑看,新版标准遵循人才发展规律、职业教育规律,注重中高本一体化设计;从内在逻辑看,标准文本要素自洽,具有清晰的逻辑理路。在实践应用中,应把握教学标准与各级各类标准、与学校人才培养方案、与认证评价的关系,需关注标准的时效性与新变化、普适性与个性化、局限性与创新性等方面的关系。

摘要：国家“双高计划”是立足教育整体发展的引领性制度设计。第一轮5年投入700多亿元,建成197所院校、253个高水平专业群,覆盖18个专业大类,人才培养和技术创新服务能力整体提升。但是,也存在专业群建设集群效应发挥不明显、育人成效的关注度不够、立地式研发成果还不强等问题。第二轮以“办学能力高水平、产教融合高质量”为目标,由“基础好、条件好”向“服务好、支撑好”转变,为实现该目标,要以思政引领力、人才竞争力、科技支撑力、民生保障力、社会协同力、国际影响力为目标指引,对接国家重大战略,深化职业教育教学改革,优化人才供给质量和结构,推动职业教育服务区域发展、支撑产业发展、完善教育对外开放,加快实现建成教育强国的宏伟目标。

摘要：The fundamental measurement of space gravitational wave detection is to monitor the relative motion between pairs of freely falling test masses using heterodyne laser interferometry to a precision of 10 pm. The masses under test are millions of kilometers apart. The inter-spacecraft laser interferometry telescope deliver laser efficiently from one spacecraft to another. It is an important component of the gravitational wave detection observatory. It needs to meet the requirements of large compression ratio, high image quality and extraordinary stray light suppression ability. Based on the primary aberration theory, the method of the large compression ratio off-axis four-mirror optical system design is explored. After optimization, the system has an entrance pupil of 200 mm, compression ratio of 40 times, scientific field of view (FOV) of ±8 μrad. To facilitate suppressing the stray light and delivering the laser beam to the back-end scientific interferometers, the intermediate images and the real exit pupils are spatially available. Over the full FOV, the maximum root mean square (RMS) wavefront error is less than 0.007λ, PV value is less than 0.03λ (λ = 1064 nm). The image quality is approached to the diffraction-limit. The TTL noise caused by the wavefront error of the telescope is analyzed. The TTL noise in the image space of 300 μrad range is less than 1 × 10-10 m whose slope is lower than 0.6 μm/rad, which is under the noise budget of the laser interferometer space antenna (LISA), satisfying the requirements of space gravitational wave detection.

摘要：文章针对北京市南水北调团城湖至第九水厂输水工程(二期)中面临的复杂外部条件、更高内外水压和更长的掘进距离等问题,围绕工程总体布置、隧洞结构设计、防水降糙、盾构施工等方面开展系统性研究。通过构建大埋深、少扰动的隧洞输水布局,分析受力特点,解决变形缝强化止水、隧洞表面降糙等技术难题;构建泥水盾构全过程技术体系,确保工程顺利实施,实现“输水环路”的封闭成环、双向输水,提高首都北京供水安全保障,并为其他相关工程的设计施工提供借鉴与参考。

摘要：针对一类具有延迟时变全状态约束的不确定非线性系统,提出自适应神经网络容错控制策略。首先,设计平移函数使违反约束的系统初值在预定时间回到约束范围内。其次,通过设计应用范围更广的新型非线性状态变换函数,将约束系统转化为无约束系统,解决全状态约束问题。接着,利用径向基神经网络和自适应技术分别处理不确定性和执行器故障。然后,根据Lyapunov理论证明闭环系统的实际有限时间稳定性,且所有状态都能保持在约束范围内。最后,通过机械臂系统的对比仿真验证设计的自适应容错控制策略的有效性。

摘要：乳腺癌是异质性较高的恶性肿瘤,不同个体病理表现、组织结构、形态、纹理特征及治疗效果等存在很大差异,针对乳腺癌异质性进行评价对个体化治疗方案设计及疗效预测具有重要意义。目前,利用多模态MRI可以敏感地评价病变范围、形态、边缘、内部强化方式及时间-信号强度曲线、表观扩散系数等信息,有望实现乳腺癌异质性的有效预测。人工智能在乳腺癌异质性多模态MRI评价方面具有较高的临床指导意义。本文基于人工智能乳腺癌异质性多模态MRI评价的研究进展进行综述,以提高乳腺癌的个体化诊治水平。

摘要：对已知具有生物活性结构的基团进行对接拼合,设计合成了含双吲哚、苯并噻喃结构的3,3'-((4-氯-2H-硫色烯-3-基)亚甲基)双(1H-吲哚)类化合物.进行了目标化合物对6株肿瘤细胞的抗肿瘤实验,结果表明3,3'-((4-氯-2H-硫色烯-3-基)亚甲基)双(5-甲氧基-1H-吲哚)(5b)、3,3'-((4-氯-7-甲基-2H-硫色烯-3-基)亚甲基)双(5-甲基-1H-吲哚)(5f)和3,3'-((4-氯-7-甲基-2H-硫色烯-3-基)亚甲基)双(N-甲基-2-甲基-吲哚)(5g)对肿瘤细胞抗增殖活性较好.拓扑异构酶抑制实验结果表明,化合物5b、3,3'-((4-氯-2H-硫色烯-3-基)亚甲基)双(6-氰基-1H-吲哚)(5c)、5f和5g对DNA拓扑异构酶II有选择性抑制活性,其它化合物对DNA拓扑异构酶II表现出不同程度抑制活性.分子对接研究结果表明,化合物5b和5g与DNA拓扑异构酶II产生了较为稳定的结合,具有潜在的抗肿瘤药物研究价值.

摘要：利用太阳能将CO_(2)转化为增值燃料,对于实现全球碳中和的目标具有重要意义,而光生电荷的有效分离是提高光催化CO_(2)还原效率的重要影响因素.在此,我们报道了一种简易的原位剥离和转化策略,将CeO_(2)纳米颗粒均匀分布在超薄多孔C_(3)N_(4)纳米片上,合成了新型的CeO_(2)/C_(3)N_(4)异质结构.C_(3)N_(4)的超薄多孔结构不仅可以增加比表面积以提供更多的活性位点,还可以有效缩短光生电子空穴的迁移距离以避免复合.此外,高度分散的CeO_(2)与C_(3)N_(4)之间具有紧密的界面接触,使更多的电荷通过界面进行转移.合成的CeO_(2)/C_(3)N_(4)异质结构具有带隙匹配的Z型结构,可以有效延长光诱导电荷载流子的寿命并提升光催化剂的氧化还原能力.与传统块状C_(3)N_(4)相比,合成的CeO_(2)/C_(3)N_(4)异质结在没有贵金属作为助催化剂和没有牺牲剂条件下显示出约5倍的CO_(2)光还原性能的提升.这项工作为用于可持续能源转换的直接Z型光催化剂的设计和实际应用提供了一种新策略.

摘要：A cylindrical negative Poisson's ratio(CNPR) structure based on two-dimensional double-arrow negative Poisson's ratio(NPR)structure was introduced in this paper. The CNPR structure has excellent stiffness, damping and energy absorption performances,and can be applied as spring, damper and energy absorbing components. In this study, the CNPR structure was used as a jounce bumper in vehicle suspension, and the load-displacement curve of NPR jounce bumper was discussed. Moreover, the influences of structural parameters and materials on the load-displacement curve of NPR jounce bumper were specifically researched. It came to the conclusion that only the numbers of cells and layers impact the hardening displacement of NPR jounce bumper. And all parameters significantly affect the structure stiffness at different displacement periods. On the other hand, the load-displacement curve of NPR jounce bumper should be in an ideal region which is difficult to be achieved applying mathematical optimization method. Therefore, a parametric design strategy of NPR jounce bumper was proposed according to the parametric analysis results. The design strategy had two main steps: design of hardening displacement and design of stiffness. The analysis results proved that the proposed method is reliable and is also meaningful for relevant structure design problem.