摘要：Reducing crop loss to diseases is urgently needed to meet increasing food production challenges caused by the expanding world population and the negative impact of climate change on crop ***-resistant crops can be created by expressing endogenous or exogenous genes of interest through transgenic ***,enhanced resistance by overexpressing resistance-produced genes often results in adverse developmental *** open reading frames(uORFs)are translational control elements located in the 5′untranslated region(UTR)of eukaryotic mRNAs and may repress the translation of downstream *** investigate the function of three uORFs from the 5′-UTR of ACCELERATED CELL 11(uORFsACD11),we develop a fluorescent reporter system and find uORFsACD11 function in repressing downstream gene *** or simultaneous mutations of the three uORFsACD11 lead to repression of downstream translation efficiency at different ***,uORFsACD11-mediated translational inhibition is impaired upon recognition of pathogen attack of plant *** coupled with the PATHOGENESIS-RELATED GENE 1(PR1)promoter,the uORFsACD11 cassettes can upregulate accumulation of Arabidopsis thaliana LECTIN RECEPTOR KINASE-VI.2(AtLecRKVI.2)during pathogen attack and enhance plant resistance to Phytophthora *** findings indicate that the uORFsACD11 cassettes can be a useful toolkit that enables a high level of protein expression during pathogen attack,while for ensuring lower levels of protein expression at normal conditions.