摘要：The intestinal epithelium is the main barrier to the oral delivery of poorly water-soluble drugs. Based on the specific transporters expressed on the apical membrane of the intestinal epithelium, novel polymer micelles targeting to the organic cation transporter 2（OCTN2） were constructed by combining carnitine conjugated poly（2-ethyl-2-oxazoline）-poly（D,L-lactide）（Car-PEOz-PLA） with monomethoxy poly（ethylene glycol）-poly（D,L-lactide）（mP EG-PLA）. The structure of the synthesized Car-PEOz-PLA was confirmed by -1H NMR, TLC and ammonium reineckate precipitation reaction, and the number-average molecular weight determined by GPC was 7260 g/mol with a low PDI of 1.44. Coumarin 6-loaded carnitine modified polymeric micelles prepared by film hydration method were characterized to have a nano-scaled size of about 31 nm in diameter, uniform spherical morphology, high drug loading content of 0.098%±0.03% and encapsulation efficiency of 92.67%±2.80%. Moreover, the carnitine-modified micelles exhibited the similar in vitro release behavior in SGF and SIF, and evidently enhanced intestinal absorption of poorly water-soluble agent. Therefore, the designed OCTN2-targeted micelles might have a promising potential for oral delivery of poorly water-soluble drugs.

摘要：In the present study, we designed and fabricated pH-sensitive polymeric micelles based on the conjugate of poly（2-ethyl-2-oxazoline）-poly（D,L-lactide）（PEOz-PLA） with doxorubicin（PEOz-PLA-imi-DOX） to efficiently inhibit tumor cell growth. hence, PEOz-PLA-imi-DOX was successfully synthesized by connecting DOX to the hydrophobic end of pH-sensitive PEOz-PLA via acid cleavable benzoic imine linker and characterized by 1 H NMR spectrum and thin layer chromatography. The critical micelle concentration of PEOz-PLA-imi-DOX was determined to be（14.84±3.85） mg/L. The conjugate micelles（denoted as PP-DOX-PM） formed by PEOz-PLA-imi-DOX using film-hydration method were characterized to have a nano-scaled size of about 21 nm in diameter, and the drug loading content was 1.67%. PP-DOX-PM showed pH-dependent drug release behavior with gradually accelerated release of DOX with decrease of pH value, illustrating the micelles＇ distinguishing feature of endo/lysosomal pH from physiological pH by accelerating drug release. As anticipated, PP-DOX-PM maintained the cytotoxicity of DOX against MDA-MB-231 cells. Collectively, PP-DOX-PM might have great potential for effective suppression of tumor growth.

摘要：To ensure the delivery of antitumor drugs to tumor site and quick release in tumor cells, we designed and prepared pH-sensitive polymeric micelles by combining cationic ring-opening polymerization of 2-ethyl-2-oxazoline （EOz） with vitamin E succinate （VES）, and then encapsulating paclitaxel （PTX） into the micelles self-assembled by poly（2-ethyl-2-oxazoline）-vitamin E succinate （PEOz-VES）. The structure of the synthesized PEOz-VES was confirmed by ^1H NMR spectrum, and the molecular weight measured by GPC was 1212 g/mol. The pKa of PEOz-VES with a low critical micelle concentration of （5.84±0.02） mg/L was determined to be 6.01. The PTX-loaded PEOz-VES polymeric micelles prepared by film hydration method were characterized to have a nanoscaled size of about 30 nm in diameter, a positive Zeta potential of 4.86 mV and uniform spherical morphology by TEM observation. The drug loading content and encapsulation efficiency were （2.63±0.16）% and （84.1±3.38）%, respectively. The in vitro release behavior of PTX from PEOz-VES micelles in PBS displayed pH-dependent pattern and was gradually accelerated with decrease of pH value, implying that the micelles could distinguish endo/lysosomal pH and tumor extracellular pH from physiological pH by accelerating drug release. Therefore, the designed PEOz-VES micelles might have significant promise for anti-cancer drug delivery.

摘要：压褶因其良好的立体效果,广泛应用于面料设计中。现有压褶面料大多采用机械压褶获得,这对原料的耐热性有一定要求,限制了原料的种类。文章提出利用特殊打纬方式和纱线间收缩性差异两种直接织造方法实现面料的压褶效果,既可增加原料种类,又能省去中间压烫工序。通过对这两种方法织造所获得的试样进行分析比较,最终选择铺设弹性纱的方式,织造1、2、3 cm三种不同褶皱宽度的压褶效果试样,并对三种试样进行弹性回复测试,结果表明铺设弹性纱方式可成功织造出保形性较好的压褶效果褶皱机织物。

摘要：城市社会经济的持续发展促成城市文化功能的增长,进而寻求城市空间的支持。城市文化空间作为承载文化功能的载体,在城市发展进程中体现出一定的阶段性、类型化特征。文章对北京自改革开放以来文化遗产、文化服务和文化产业的承载空间发展历程做了概要梳理,对其空间规模、范围和分布做了初步分析,并简要研判了其主要影响因素,勾勒了北京近40年来城市文化空间发展演进的主要特征。

摘要：在我国城市经历了快速城市化进程后,城市更新成为转型发展的重要途径。低碳生态和高质量发展是目前城市更新中的关键议题。“山城火炉”重庆在过去40年的快速扩张发展后,亟需探索可持续的城市更新路径。尚未更新的九龙半岛成为研究和规划设计的典型地区。本文从生态、历史、产业、社会、交通等方面分析了九龙半岛的资源禀赋,判断其具有成为中心城区凉岛绿心、建构地区级历史资源体系和成为世界级双年展场的潜力,据此提出将“清凉慢岛”作为其发展定位。规划设计围绕“清凉”和“慢”两大主题,通过“清凉生态”“低碳交通”“慢体验”“慢创作”和“慢生活”五大策略,谋划由总体规划到地段设计的更新路径,并探索实施保障。本文试图建构一种比较视野下的面向生态和经济的定性、定量分析方法,并落实到设计方案中,提出对存量地区更新的多维度解决方案。

摘要：为了明确不同食物种类和饲养基质对门源蝠蛾幼虫生长发育的影响,完善门源蝠蛾幼虫的饲养方法,以刚蜕皮的3龄幼虫为研究对象,采用双因素试验设计,使用4种食物(Z1:珠芽蓼、J2:蕨麻、D3:大黄、H4:胡萝卜)和3种饲养基质(基于自然条件下最适宜的G1:高寒土、人工饲养较适宜的Y2:发酵椰糠粉、一般性饲养基质适宜性较低的N3:泥炭土),采用灰色关联度分析法,通过分析6种营养物质的含量,包括粗蛋白(Crude protein,CP)、粗纤维(Crude fiber,CF)、可溶性糖(Soluble sugar,SS)、粗灰分(Crude ash,Ash)、水分含量(H2O)和碳水化合物含量(carbohydrate,CHO),对4种食物的营养水平进行综合评价,分析食物种类和饲养基质对幼虫头宽、体长、体重和成活率的影响。结果显示,4种食物富含的营养物质各有差异,综合营养水平为Z>J>D>H(P体重>体长>存活率;饲养基质与头宽、体长、体重、存活率均呈显著正相关(P头宽>体长>存活率(P<0.05)。食物种类对头宽的促进作用最大,饲养基质对体重的促进作用最大。以珠芽蓼为食源,以高寒土为饲养基质,门源蝠蛾幼虫生长发育最好。

摘要：模态分析可以获得结构的动特性参数。对32级模块化Marx发生器机芯进行了力学特性仿真分析和模态试验,用以评估Marx发生器的力学环境适应性。首先,建立了模块化Marx机芯的有限元模型,获得了初步振型;其次,在自由边界条件下分别开展了Marx机芯整体模态试验、局部模态试验和传递特性试验,得到了整体和局部结构的模态参数。研究表明,模块化Marx机芯在23.58 Hz处出现整体一阶扭转;机芯局部结构固有频率较高;机芯在x,y,z三个方向的振动传递率的范围分别为5~15,6~10和10~35,为后续工程中Marx发生器机芯的针对性设计提供了参考。

摘要：通过对人口老龄化和房地产开发两个焦点问题的关注,我们在充分认识老年人口问题严重性的同时,试图尝试新的房地产模式以容纳老中青三代人,在帮助开发商获得最大利益的同时,也可以积极主动地减缓社会承担养老责任的压力,帮助开发商完成社会使命。通过一种新的视野来整合两个交叉学科的缺口,以达一举两得的成效。