摘要：Con.ext: Basic r.sear.h pr.vides plausible mechan.sms an. obser.ation.l studies suggest that appar.n.ly healthy per.on., who self-select for.high in.akes of vitamin.E thr.ugh diet or.supplemen.s, have decr.ased r.sks of car.iovascular.disease an. can.er. r.n.omized tr.als do n.t gen.r.lly suppor. ben.fits of vitamin.E, but ther. ar. few tr.als of lon. dur.tion.amon. in.tially healthy per.on.. Objective: To test whether.vitamin.E supplemen.ation.decr.ases r.sks of car.iovascular.disease an. can.er.amon. healthy women. Design. Settin., an. Par.icipan.s: In.the Women.s Health Study con.ucted between.1992 an. 2004, 39 876 appar.n.ly healthy US women.aged at least 45 year. wer. r.n.omly assign.d to r.ceive vitamin.E or.placebo an. aspir.n.or.placebo, usin. a 2×2 factor.al design. an. wer. followed up for.an.aver.ge of 10.1 year.. In.er.en.ion. Admin.str.tion.of 600 IU of n.tur.l-sour.e vitamin.E on.alter.0}te days. Main.Outcome Measur.s: Pr.mar. outcomes wer. a composite en. poin. of fir.t major.car.iovascular.even.(n.n.atal myocar.ial in.ar.tion. n.n.atal str.ke, or.car.iovascular.death) an. total in.asive can.er. r.sults: Dur.n. follow-up, ther. wer. 482 major.car.iovascular.even.s in.the vitamin.E gr.up an. 517 in.the placebo gr.up, a n.n.ign.fican. 7%r.sk r.duction.r.lative r.sk[r.], 0.93; 95%con.iden.e in.er.al[CI], 0.82-1.05; P=.26). Ther. wer. n. sign.fican. effects on.the in.iden.es of myocar.ial in.ar.tion.r., 1.01; 95%CI, 0.82-1.23; P=.96) or.str.ke(r., 0.98; 95%CI, 0.82-1.17; P=.82), as well as ischemic or.hemor.hagic str.ke. For.car.iovascular.death, ther. was a sign.fican. 24%r.duction.r., 0.76; 95%CI, 0.59-0.98; P=.03). Ther. was n. sign.fican. effect on.the in.iden.es of total can.er.1437 cases in.the vitamin.E gr.up an. 1428 in.the placebo gr.up; r., 1.01; 95%CI, 0.94-1.08; P=.87) or.br.ast(r., 1.00; 95%CI, 0.90-1.12; P=.95), lun.(r., 1.09; 95%CI, 0.83-1.44; P=.52), or.colon.can.er.(r., 1.00; 95%CI, 0.77-1.31; P=.99). Can.er.deaths also did n.t differ.sign