摘要：DNA methyl transferase(DNMT) and histone deacetylase(HDAC) are well recognized epigenetic targets for discovery of antitumor *** this study,we designed and synthesized a series of nucleoside base hydroxamic acid derivatives as DNMT and HDAC dual *** assays and enzymatic inhibitory activity tests indicated that compound 204 exhibited potent DNMT1 and HDAC1/6 inhibitory potency simultaneously in enzymatic levels and at cellular levels,inducing hypomethylation of p16 and hyperacetylation of histones H_(3) K9 and H4 ***,204 remarkably inhibited proliferation against cancer cells U937 by prompting G0/G1 cell cycle *** docking models explained the functional mechanism of 204 inhibiting DNMT1 and *** studies on metabolic profiles revealed that 204 showed desirable stability in liver *** study suggested that 204 inhibiting DNMT and HDAC concurrently can be a potential lead compound for epigenetic cancer therapy.

摘要：Porous g-C_(3)N_(4)nanosheets(PCN)were prepared by the nickel-assisted one-step thermal polymerization ***(H2)which was produced by the reaction between nickel(Ni)foam and ammonia(NH3)defined the structure and properties of *** the formation of PCN,the participation of H2 not only enhanced the spacing between layers but also boosted the specific surface area that more active sites were ***,H2 promoted pores formation in the nanosheets,which was beneficial to the transfer of photons through lamellar structure and improved the absorption efficiency of visible ***,the obtained PCN possessed better Cr(Ⅵ)photocatalytic reduction efficiency than pure g-C_(3)N_(4).The reaction rate constant(k)of PCN(0.013 min-1)was approximately twice that of bare g-C_(3)N_(4)(0.007 min-1).Furthermore,the effects of original pH and concentration of Cr(Ⅵ)-containing solution on re moval efficiency of Cr(Ⅵ)were explored.A possible photocatalytic mecha nism was proposed based on the experiments of radical scavengers and photoelectrochemical characterizations.

摘要：文章探讨了地质雷达在复杂地质条件下隧道勘探中的应用。对复杂地质条件对隧道施工的影响进行了分析,重点介绍了地质雷达在隧道地质勘探中的关键作用,以及数值模拟技术在解决复杂地质问题中的优势。在理论层面,着重阐述了地质雷达的基本原理以及数据处理方法,并通过运用gprMax软件设计实验,研究尺寸因素对目标体的影响。结合湖南永州紫金山3号隧道工程项目的案例,使用地质雷达采集数据并验证了数值模拟的结果。在这一实例中,有效地应用了地质雷达技术,预测了隧道掘进面前的断层破碎区及其断层位移,这为工程操作提供了重要的指引和帮助。这些发现不仅深化了大家对地质雷达在隧道勘探中应用的认识,同时也为复杂地质环境下的隧道工程施工提供了实际可行的预警和探测手段。

摘要：根据数百个洁净厂房的设计、施工实践经验,深入研究了洁净厂房各类深化设计节点构造做法,内容涵盖洁净工程的十几个主要分部分项工程。相关研究成果,填补了国内行业空白。课题成果出版发行以后,可以为国内洁净工程项目的深化设计工作提供指导和借鉴。

摘要：In order to design the scale model in a wide frequency range,a method based on the reflective loss is proposed according to the high-frequency approximation algorithm,and an example of designing the scale model of a plate-shaped absorber is given in this *** the example,the frequency of the full-size measurement ranges from 2.0 GHz to 2.4 GHz,the thickness of the full-size absorber is 1 mm and the scale ratio is 1/5.A two-layer scale absorber is obtained by the proposed *** thickness values of the bottom and top layer are 0.4 mm and 0.5 mm,***,the scattering properties of a plate model and an SLICY model are studied by FEKO to verify the effectiveness of the designed scale *** with the corresponding values from the theoretical scale model,the average values of the absolute deviations in 10 GHz～12 GHz are 0.53 d Bm^2,0.65 d Bm^2,0.76 d Bm^2 for the plate model and 0.20 d Bm^2,0.95 d Bm^2,0.77 d Bm^2 for the SLICY model while the incident angles are 0°,30°,and 60°,*** deviations fall within the Radar cross section（RCS） measurement ***,the work in this paper has important theoretical and practical significance.

摘要：Two types of Mg-Cu composition system graded density impactors used for complex loading （shock loading and quasi-isentropic compression） are designed by the elastic-plastic hydrodynamic method in this paper. Mixtures of metal powders in the Mg-Cu system are cast into a series of 17 and 25 uniform compositions ranging from 100% Mg to 100% Cu. The graded den- sity impactors are launched to the stationary 10 Ixm aluminum film and 12 mm LiF window targets by a two-stage light-gas gun in the National Key Laboratory for Shock Wave and Detonation Physics Research, Institute of Fluid Physics, CAEP, and the resulting wave profiles are measured with the DISAR system. Hydrodynamic simulation results are perfectly consistent with the experiments. Our work in this paper will set up a foundation for further research of controllable loading/releasing routes and rate experiments in the future.

摘要：The integration and accommodation of the wind and solar energy pose great challenges on today’s power system operation due to the intermittent nature and volatility of the wind and solar *** efficient large-scale electrical energy storage is one of the most effective and economical solutions to those *** the comprehensive review of the existing storage technologies,this paper proposes an overall design scheme for the Non-supplementary Fired Compressed Air Energy Storage(NFCAES)system,including system design,modeling and efficiency assessment,as well as protection and ***,the design principles of the multistage regenerative,*** recovery system which is used to fully recycle and utilize the waste heat from compression are provided,so as the overall system efficiency evaluation *** paper theoretically ascertains the storage decoupling rules in the potential and internal energy of molecular compressed air and reveals the conversion mechanism of gas,heat,power,electricity and other forms of *** this basis,a 500-k W physical simulation system of CAES system(TICC-500,Tsinghua-IPCCAS-CEPRI-CAES)is built,which passed a system-wide 420-k W load power generation test with less pollution and zero carbon ***,the multi-form energy conversion of multi-stage regenerative CAES and storage efficiency is verified,especially its incomparable superiority in solving the uncertainty problem in wind and solar power ***,the propaganda and application scenario of the CAES system in China is introduced.

摘要：Both in ancient China and Western countries educators emphasized cultivation of students’emotions, personalityand character, among whom Confucius, the great Chinese thinker and educator and Locke, the famous Britishpolitical thinker, philosopher and educator are two representative figures. The former contended the primaryconcern on cultivation of Junzi, an idealized personality with virtue and righteousness and the latter pushed themodern Western gentleman education to the summit under the unique British noble system and the tradition ofelite education. This paper makes a contrastive study of Confucius’s Junzi education and Locke’s gentlemaneducation. Through analyzing and comparing the unique Confucian moral principles and Locke’s insights intogentleman education, the study finds that although there are common grounds and similarities between ConfucianJunzi education and Locke’s gentleman education, they are different from each other in teaching target groups,teaching methods and teaching contents. This study helps to bring a significant rethinking for charactercultivation and enrich the contemporary educational ideas from a cross-cultural perspective.

摘要：A C-band polarization rotator-splitter based on a mode-evolution structure and an asymmetric directional coupler is proposed. The mode-evolution structure is designed in a bi-level taper through which the TM;mode can evolve into the TE;mode. Then the TE;mode is coupled to the TE;mode at the cross port using the asymmetric directional coupler. The input TE;mode propagates along the waveguide without mode conversion and output at the through port. From the experimental results, the extinction ratio is lower than 30 dB and the excess loss is less than 1 dB for input TE;mode at the whole C-band. For input TM;mode, the ER and the EL are, respectively,lower than-10 and 1.5 dB.

摘要：The advent of the 5G era has stimulated the rapid development of high power electronics with dense ***-dimensional(3D)thermally conductive networks,possessing high thermal and electrical conductivities and many different structures,are regarded as key materials to improve the performance of electronic *** provide a critical overview of carbonbased 3D thermally conductive networks,emphasizing their preparation-structure-property relationships and their applications in different scenarios.A detailed discussion of the microscopic principles of thermal conductivity is provided,which is crucial for increasing *** is followed by an in-depth account of the construction of 3D networks using different carbon materials,such as graphene,carbon foam,and carbon *** for the assembly of two-dimensional graphene into 3D networks and their effects on thermal conductivity are ***,the existing challenges and future prospects for 3D carbon-based thermally conductive networks are discussed.