摘要：“势”原是一种内涵丰富的书学专论文体。汉末至西晋期间,“势体文”从初兴直至鼎盛具备了特定的历史条件:一是书体和文体大备;二是书论和文论昌明。作为早期书学和文学交汇发展的产物,势体文不但显著地标志着书学史上书法艺术的提升和书法审美的自觉,而且集中地反映了文学史上文体意识的进步和文体理论的成熟。此外,它由盛而衰的轨迹还可折射出其时书风移变和文体竞争的影响,从而为观照中古“技艺”文体兴衰浮沉现象背后的复杂原因提供合理的解释和参考。

摘要：目的优化羌芩颗粒的干法制粒成型工艺,并对颗粒进行质量控制。方法以颗粒成型率、吸湿率(H)、溶化率和休止角(α)的综合评分为指标,采用Box-Behnken设计-响应面法结合AHP-CRITIC混合加权法建立干法制粒关键工艺参数(critical process parameters,CPPs)和关键质量属性(critical quality attributes,CQAs)的数学模型,通过该模型构建干法制粒的设计空间,并进行蒙特卡洛验证。采用单形格子设计对满足制粒工艺的甘露醇、麦芽糊精、糊精进行辅料配比筛选,确定最佳辅料配比并进行验证。采用粉体学评价方法对羌芩颗粒各项物理质量属性指标进行综合表征,建立由松装密度(Da)、振实密度(Dc)、α、豪斯纳比(IH)、H、含水量(HR)、颗粒间孔隙率(Ie)、卡尔指数(IC)、比表面积(SSA)、粒径<50μm百分比(Pf)、分布宽度(span)、分布范围(width)、均匀性(HG)共13个二级物理质量指标构成的颗粒物理指纹图谱,评价不同批次间颗粒质量的一致性。结果羌芩颗粒干法制粒CPPs的设计空间为送料频率37~45 Hz,滚轮频率8.0~11.8 Hz,滚轮压力40~50 kg/cm^(2)。最佳辅料配比为甘露醇86%,糊精14%。15批样品物理指纹图谱的相似度均大于0.95。结论优选后的羌芩颗粒干法制粒成型工艺稳定可行,中间体物理性质质量评价科学合理,可为中药新药的开发及工业化放大生产提供参考。

摘要：可编程柔性蒙皮在软体机器人、柔性电子和柔顺机构等领域具有重要的应用价值.然而,现有许多基于跃变结构蒙皮往往在进行力学阈值和工作行程设计时,存在阈值和行程耦合且设计参数空间有限等问题,限制了其在前述各个领域灵活应用.通过将约束结构引入跃变结构,本文提出了一种力学阈值和工作行程可同时编程的柔性结构蒙皮设计方法.首先,通过系统地表征基本跃变结构的力学阈值和工作行程与关键结构参数的关系,本文拟合了力学阈值和工作行程与结构参数的数学关系;进一步地,通过引入约束结构对其工作行程进行约束,建立了该约束结构的结构参数和工作行程的数学映射;最后,基于所提出的结构约束型可编程柔性跃变结构蒙皮,实现了在力学阈值几乎不变的条件下对蒙皮工作行程的精确调控,并验证了该方案对多级梯度行为调控的可行性.简而言之,本文所提出的方法极大简化了柔性蒙皮力学阈值和工作行程协同设计,拓宽了其设计参数空间,并使得跃变过程更加平顺,有助于实现柔性蒙皮在软体机器人、柔性电子等领域广泛灵活的应用.

摘要：The cross-coupled control(CCC)is widely applied to reduce contour errors in contour-following *** such situation,the contour error estimation plays an important ***,the linear or second-order estimation approach is adopted for biaxial motion systems,whereas only linear approach is available for triaxial *** this paper,the second-order contour error estimation,which was presented in our previous work,is utilized to determine the variable CCC gains for motion control systems with three *** integrated stable motion control strategy,which combines the feedforward,feedback and CCC controllers,is developed for multiaxis CNC *** results on a triaxial platform indicate that the CCC scheme based on the second-order estimation,compared with that based on the linear one,significantly reduces the contour error even in the conditions of high tracking feedrate and small radius of curvature.

摘要：This paper addresses the problem of accuracy characterization and measurement point planning for 3-D workpiece localization in the presence of part surface errors and measurement errors. Two frame-invariant functions of the infinitesimal rigid body displacement are defined to quantify the localization accuracy required by manufacturing processes. Then, two kinds of frame-invariant indices are derived to characterize the sensitivities of the accuracy measures to the sampling errors at the measurement points. With a dense set of discrete points on the workpiece datum surfaces pre-defined as candidates for measurement, planning of probing points for accurate recovery of part location is modeled as a combinatorial problem focusing on minimizing the accuracy sensitivity index. Based on an interchange rule, a greedy algorithm is developed to efficiently find a near-optimal solution. It is also shown that if the number of the measurement points is sufficiently large, there is no need to optimize their positions. Example confirms the validity of the presented indices and algorithm.

摘要：目的 筛选经典名方一贯煎的最优提取工艺,为其制剂研究提供实验依据。方法 对HPLC法测定的甜菜碱、地黄苷D、对香豆酸、阿魏酸、毛蕊花糖苷、洋川芎内酯Ⅰ进行化学计量学分析;以筛选出的关键成分含量、出膏率及指纹图谱相似度为评价指标,采用改进AHP-熵权法确定各个指标的组合权重系数,以基准样品关联度评价样品与基准样品的质量一致性,在单因素试验的基础上,采用响应面法优选一贯煎的提取工艺参数。结果 Box-Behnken设计建立的数学模型具有统计学意义,一贯煎最佳提取工艺参数为加12倍量水,提取时间80 min,提取2次。此条件下设计空间的综合评分为0.963。结论 采用改进AHP-熵权-基准样品关联度法优选一贯煎提取工艺参数,所拟合的模型显著,与基准样品质量基本一致,为进一步研究经典名方一贯煎复方制剂究提供了参考。

摘要：医疗保障基金的合理使用对于推进公立医院高质量发展起着重要作用,基金监管呈法治化、常态化、专业化、规范化态势,飞行检查工作将成为常态。作者系统分析了医疗保障基金飞行检查的3个主要趋势特征,即力度逐渐加大、手段不断创新、后果愈加严重,并从结果表现形式、严重程度、归属范围、有无主观意愿和监管筛查思路5个维度梳理飞行检查中暴露的问题;从合规意识、组织体系、精细管理和日常监管4个方面出发,探索医疗保障基金飞行检查对于医院管理的启示,提出公立医院应转换角色与站位,健全部门协同配合的工作机制,在政策理解、制度制定、流程设计、信息支撑、数据治理、监管落实、人员培训和绩效配套方面做到精细管理"八个到位",同时应将医院内部模拟飞行检查作为常态化工作。

摘要：无定形态固体分散体能显著提高难溶性药物的溶解度和生物利用度,但其在制备或储存过程中容易发生结晶而削弱原有的优势。固体分散体中的无定形态药物结晶过程分为成核和晶体生长两步,其中成核是结晶的起始环节和关键步骤,但目前尚对无定形态药物结晶成核认识还很有限。本文对无定形态药物成核的研究方法、成核理论、添加物影响成核的机制及成核影响因素进行归纳,期望为无定形态固体分散体处方设计和提高其物理稳定性提供理论指导。

摘要：Distinguishing with traditional tooth profile of spiral bevel and hypoid gear, it proposed a new tooth profile namely the spherical involute. Firstly, a new theory of forming the spherical involute tooth profile was proposed. Then, this theory was applied to complete parametric derivation of each part of its tooth profile. For enhancing the precision, the SWEEP method used for formation of each part of tooth surface and G1 stitching schema for obtaining a unified tooth surface are put forward and made the application in the accurate modeling. Lastly, owing to the higher accuracy of tooth surface of outputted model, it gave some optimization approaches. Given numerical example about the model can show that this designed gear with spherical involute tooth profile can achieve fast and accurate parametric modeling and provide a foundation for tooth contact analysis （TCA） in digitized design and manufacture.

摘要：How to identify all feasible assembly sequences and compactly represent them is very important and necessary to computer-aided assembly sequence planning. An approach to get precedence relationships between components directly from assembly modeling is proposed in this paper. A representation method called disassembly sequence graph (DSG) is also presented in this paper. An example has been provided to illustrate the proposed approach.