摘要：To discover an efficient route for the shift from an antibacterial fluoroquinolone to an antitumor one based on the mechanistic similarities between targeting topoisomerases and the eukaryotic ones,two series of the title compounds,C3 bis-oxadiazole methylsulfides 6a―6h and corresponding dimethylpiperazinium iodides 7a―7h derived from levofloxacin 1 were designed and *** in vitro antiproliferative activities against Chinese hamster ovary cell line（CHO）,murine leukemia cell line（L1210） and human leukocytoma cell line（HL60） were evaluated by MTT assay,and inhibitory effect on DNA topoisomerase IIα was also measured by means of densitometric assay.

摘要：快速原型技术和逆向工程相结合可以提高柴油机进排气道的模具和铸件的精度,缩短模具开发周期。利用数字化测量设备获取实体点云数据,在CATIA环境下对这些点云数据进行拟合,构建一个完整的CAD模型,然后采用Pro/E软件设计进排气道的模具,在MasterCAM环境下生成其模具数控加工程序。

摘要：In recent years, it has been demonstrated that checklists can improve patient safety significantly. To facilitate the effective use of checklists in daily practice, both the medical community and the informatics community propose to implement checklists in dynamic checklist applications that can be integrated into the clinical workflow and that is specific to the patient context. However, it is difficult to develop such applications because they are tightly intertwined with the content of specific checklists. We propose a platform that enables access to dynamic checklist applications by configuring the infrastructures provided in the platform. Then, the applications can be developed without time-consuming programming work. We define a number of design criteria regarding point of care and clinical processes by analyzing the existing checklist applications and the lessons learned from ***, by applying rule-based clinical decision support and workflow management technologies, we design technical mechanisms to satisfy the design criteria. A dynamic checklist application platform is designed based on these mechanisms. Finally, we build a platform in various design cycle iterations, driven by multiple clinical cases. By applying the platform, we develop nine comprehensive dynamic checklist applications with 242 dynamic *** results demonstrate both the feasibility and the overall generic nature of the proposed approach. We propose a novel platform for configuring dynamic checklist applications. This platform satisfies the general requirements and can be easily configured to satisfy different scenarios in which safety checklists are used.

摘要：为保证硬件设计的正确性,提出了对硬件设计组合验证的新方法.该方法在命题投影时序逻辑的统一框架下,实现对硬件系统行为的建模,对所期望性质的形式化描述,并利用命题投影时序逻辑合理且完备的公理系统对系统性质进行验证,从而证明硬件系统满足期望的性质,保证设计的正确性.进位保留加法器的验证实例说明了该方法的可行性。

摘要：Two-dimensional layered double hydroxides(LDHs)have been identified as promising electrocatalysts for the oxygen evolution reaction(OER);however,the simple and effective synthesis of high-quality LDHs remains extremely challenging and the active sites have not been ***,we report a facile solution-reaction method for preparing an ultrathin(thickness<2 nm)nonprecious CoFe-based ***_(1)Fe_(0.2) LDH delivers a current density of 10 mA cm^(-2) and a high turnover frequency of 0.082 s^(-1) per total 3d metal atoms at a low overpotential of 256 *** mass activity is 277.9 A g^(-1) at an overpotential of 300 mV for the *** studies reveal the Co site as the main active center for the *** doped Fe lowers the reaction barrier by accelerating the charge-transfer *** calculations reveal that the surface Co sites adjacent to Fe atoms are the active centers for the OER and the subsurface Fe dopants excessively weaken the OH^(*)adsorption,thus increasing the energy barrier of the rate-determining *** study can guide the rational design of high-performance CoFe-based LDHs for water splitting.

摘要：生产能力的缩放性设计是可重构制造系统(RMS)的主要研究内容之一.针对缺乏具有可操作性的生产能力重构方法的问题,提出了具有动态特性的约束RMS生产能力扩展性重构方法.通过分析生产能力缩放性原理,给出实现生产能力重构的3种基本方法.在给定RMS约束模型的基础上,通过建立系统成本模型、生产线平滑指数模型生成RMS生产能力扩展性设计的综合模型,并针对模型特点,提出了约束RMS生产能力扩展性设计的具体实现方法.最后通过实例验证了该方法的实用性和有效性.

摘要：论述了凸轮机构多项式运动规律的一般设计方法,在此基础上提出了一个凸轮机构多项式运动规律的改进设计方法,给出了推荐的动力性能较优的多项式运动规律。

摘要：为增强工艺知识的重用性,提高工艺规划的柔性和动态适应性,提出基于时间向量和矩阵的多工序加工系统工艺路线重组建模与优化方法。通过分析多工序的共同作用因素及工序间复杂的耦合关系,构建了基于简单插入操作的惩罚时间矩阵、换刀时间向量、定位时间向量、装夹时间向量、旋转时间向量和加工时间矩阵。在此基础上,以非切削加工时间和空闲时间最小为目标,建立了多工序加工系统工艺路线重组模型,设计了工艺路线整数线性优化重组算法。通过汽车发动机缸盖加工工艺优化重组,验证了该模型和优化算法的有效性。

摘要：应用Inventor软件对电缆卷筒进行了三维建模和虚拟装配,分析了三维建模的过程和技术要点,并由电缆卷筒的模型生成关联的工程图,提高了电缆卷筒系列化设计的效率和质量,对Inventor软件在其他产品设计中的应用有很重要的意义。

摘要：精调平台的结构参数对其运动性能有极为重要的影响。本文首先推导了并联型平台的 Jacobian矩阵 ,然后论述了选择 Jacobian矩阵的条件数作为优化设计目标函数的合理性 ,并以 Jacobian矩阵的条件数为优化设计目标函数 ,优化了精调平台的结构参数 。