摘要：Sodium taurocholate cotransporting polypeptide(NTCP)is identified as the functional receptor for HBV entry,which is responsible for upregulated HBV transcription in the HBV life ***,NTCP is also implicated in the progression of HBV-induced hepatocellular carcinoma(HCC).Thereby,NTCP-targeting entry inhibitors are proposed to suppress HBV infection and replication in HBV-induced hepatoma ***,we integrated in silico screening and chemical synthesis to obtain a small-molecule NTCP inhibitor B7,which exhibited moderate anti-proliferative activities against HepG2 cells and anti-HBV activity in ***,CETSA assay,molecular docking,and MD simulation validated that B7 could bind to ***,western blot analysis demonstrated that B7 induced apoptosis with an increased expression of Bax and caspase 3 cleaving as well as a decreasing expression of Bcl-2 in HepG2 *** together,our study identified B7 as a novel NTCP inhibitor with anti-proliferation activities which might provide a new opportunity for HCC therapy.

摘要：进入21世纪以来,中国无论是在经济还是在文化都已逐渐和世界融为了一体。当今的中国既要学习世界各国的优秀文化,同时中国也需要把自己优秀的文化介绍给世界的其他国家。该项目以社团为依托,通过社团活动和展会等手段,在手工汉饰制作和展示过程中,让更多的人了解汉民族文化的精髓与美,以达到传承和传播汉民族文化的目的。

摘要：概述了富贵虾醉制的工艺流程及操作要点,采用正交设计试验研究了富贵虾醉制生产过程中3个重要因素,即盐渍含盐量、醉制时间、醉制温度对产品品质的影响。结果表明,富贵虾醉制的最佳工艺条件为盐渍含盐量12%,醉制时间4 h,醉制温度20℃。