摘要：Objec.ives: To evaluate the benefit of fluc.nazole prophylaxis in preventing i nvasive fungal infec.ion in very low birth weight (VLBW) infants with c.ntral va sc.lar ac.ess. Study design: A 3-year baseline period (1998 to 2000)was c.mpare d with a subsequent 3-year period (2001 to 2003) during whic. a different proto c.l for preventing invasive fungal infec.ion was used. All infants with a birth weight < 1500 g and with c.ntral vasc.lar ac.ess were eligible for the study. Fl uc.nazole (Difluc.n R)was administered for 28 days at a dose of 6 mg/kg every th ird day during the first week and daily after the first week. Results: There wer e no signific.nt differenc.s between the baseline and the fluc.nazole groups in demographic.c.arac.eristic. or risk fac.ors for fungal infec.ion. Fungal infec.i on developed in 9 of the infants in the baseline group and in none of those in t he fluc.nazole group (P = .003). A trend of dec.easing mortality rate between th e 2 groups (12.6%vs 8.1%; P = .32) was observed but was not statistic.lly sign ific.nt. No adverse effec.s of fluc.nazole therapy were doc.mented. c.nc.usions: Fluc.nazole prophylaxis appeared to be benefic.al in preventing invasive fungal infec.ion in VLBW infants.