摘要：A un.que porcin. extracellular matrix (ECM) derived in.ectable tissue con.truct with 100 n. or 20 n. gold n.n.particles (Aun.) was developed for musculoskeletal tissue en.in.erin. application.. ECM has been.shown.to en.ourage cellularity an. tissue remodelin. due to its release of growth factors while Aun. have been.shown.to reduce reactive oxygen.species (ROS) levels. In.ectable tissue con.tructs were created by homogen.zin. decellularized porcin. diaphragm ten.on.con.ugated with 100 n. or 20 n. Aun. at 1x, 4x, an. 8x con.en.ration.. Extrusion.force testin. demon.trated that homogen.zed tissue con.tructs were in.ectable at an.appropriate can.ula size an. force. L-929 murin. fibroblasts were used to measure cell viability, cell proliferation. in.racellular ROS levels, an. cell migration.in.respon.e to con.tructs. En.an.ed cell viability an. proliferation.are observed on.1 × 20 n. Aun. con.tructs. ROS assays demon.trate reduced cellular ROS con.en.ration. from all 20 n. Aun. con.tructs an. from 8 × 100 n. Aun. con.tructs compared with con.tructs without n.n.particles. Cellular migration.is higher towards 4 × 20 n. Aun. con.tructs compared with con.tructs without n.n.particles. Results support the poten.ial use of a porcin. ECM derived in.ectable tissue con.truct with Aun. as an.in.ectable tissue con.truct to reduce in.lammation.an. to promote tissue remodelin. in.musculoskeletal tissue en.in.erin. application..