摘要：Accurate and fast performance estimation is necessary to drive design space exploration and thus support important design decisions. Current techniques are either time consuming or not accurate enough. In this paper, we solve these problems by presenting a hybrid method for multimedia multiprocessor system-on-chip （MPSoC） performance estimation. A general coverage analysis tool GNU gcov is employed to profile the execution statistics during the native simulation. To tackle the complexity and keep the analysis and simulation manageable, the orthogonalization of communication and computation parts is adopted. The estimation result of the computation part is annotated to a transaction accurate model for further analysis, by which a gradual refinement of MPSoC performance estimation is supported. The implementation and its experimental results prove the feasibility and efficiency of the proposed method.

摘要：本文从敦煌历史文化的价值意义研究、敦煌历史文化的借鉴与创新、设立敦煌预防医学研究体系和敦煌艺术设计学体系以与新兴学科的接轨、敦煌石窟与学科交叉、对敦煌佛教文化的重新认识等方面,提出进一步开拓敦煌研究的新领域的设想。

摘要：冯契在批判、继承中西传统美学思想的基础上,建立起系统的关于艺术及美学的思想理论,主要内容涉及当代美学研究的三个重大问题:即艺术、艺术品和艺术家。艺术或艺术活动就是人与自然、性与天道的交互作用;艺术活动以感性对象作为中介,这种感性对象一定是个性化的、体现了人的个性自由,因此艺术又是自由的活动,这种自由的艺术活动是将艺术理想化为现实。通过对冯契美学思想的解读,可以发现其中所蕴涵的当代价值。

摘要：敦煌出土的佛教版画表现了佛教信仰的一种新方式,它与敦煌石窟艺术一脉相承,是敦煌艺术的组成部分之一,是科学技术与佛教艺术相结合的产物,在中国美术史和中国印刷科技史上都有十分重要的价值意义。

摘要：敦煌莫高窟藏经洞出土的版画主要以佛教题材为主,其中有阿弥陀佛、文殊、观自在和地藏菩萨像,以及太平兴国五年(980)刻印的《大随求陀罗尼》版画,反映了佛教民间信仰的本土化和民族化特征,是五代宋初蜀地佛教版画艺术的珍贵实物见证。这不仅开启了版画作为独立创新画种的历史进程,奠定了我国古代版画艺术的雕镌、填色及上图下文等民族样式;而且带来了全新的佛教民间信仰模式、佛教题材和图像特征,为敦煌石窟艺术的发展注入了新鲜血液,成为当代人重新审视唐宋版画艺术在丝绸之路上传播的鲜活个案。

摘要：Cyclic dinucleotides(CDNs) are known to activate stimulator of interferon genes(STING) and induce type I interferon responses, therefor possess great potentials to be of immunotherapeutic value for cancers and infectious diseases. However, the existence of different single nucleotide polymorphism(SNP) of human STING(hSTING) gene poses an obstacle to achieve broad-spectrum activation by CDNs. We reported here the design and synthesis of a total of 36 CDNs, representing all structural variations, that contain four bases(A, G, C, U) and two linkage directions(2′-5′-linked and 3′-5′-linked phosphodiester).Through systematic evaluation of IFN-β induction with a dual-luciferase reporter assay, we discovered that wild type hSTING and two isoforms(HAQ and AQ) showed strong response while hSTING-R232 H and R293 Q exhibited the relatively weak response to CDNs stimulation. For the first time, we found that the c[G(2′,5′)U(2′,5′)] showed excellent activity against all five hSTING variants even equivalent to the endogenous ligand c[G(2′,5′)A(3′,5′)]. Furthermore, we have also demonstrated that 3′-3′CDNs with two 3′-5′ phosphodiesters showed higher serum and hydrolase stability than 2′-2′ CDNs with two 2′-5′ phosphodiesters and 2′-3′ CDNs with one 2′-5′ and one 3′-5′ phosphodiester. It is very interesting to note that 2′-2′ CDNs has been found for the first time to show strong activity. These findings will stimulate our exploration for the new functional role of CDNs, and provide guidelines to design CDNs based hSTING targeted drugs.

摘要：企业在实际经营过程中不可避免的会遭遇产品伤害危机(Product-Harm Crisis),危机的发生会使商誉受到折损。因此,本文旨在研究当企业预期到可能会发生产品伤害危机时的动态广告策略。为此,首先利用随机到达过程刻画危机的发生,并在此基础上建立危机影响下的动态广告模型。其次运用贝尔曼动态规划原理得到了制造商和零售商在集中、分散以及成本分担决策模式下的最优广告和成本分担策略。最后通过对结果的研究分析可以发现:产品伤害危机的预期会改变供应链成员的时间偏好,使供应链成员更重视当前而不是未来的利润;当危机发生率以及商誉折损率增大时,制造商应减少危机前的广告投入;危机发生率以及商誉折损率会影响零售商危机前的成本分担策略,但影响的结果取决于双方危机前后边际利润的情况;成本分担策略依然能够提高供应链双方的广告投入,从而提高商誉、市场需求和双方的利润,最终实现帕累托改进。

摘要：民族地区的大量民间反弹乐器表演的场景,表明了敦煌壁画中反弹琵琶的合理性。然而大量以此图像为基础创作的艺术作品,未能真正体悟和考虑壁画的整体性和乐理知识的常识性,导致出现琵琶的正、反朝向问题,未能真正传承敦煌美术技艺的精髓。因此,从事反弹琵琶壁画的艺术再创作,不仅要遵循基本常识,还需要纠正前人作品中的不合理之处,让作品更加有生命力。

摘要：铁凝对短篇小说情有独钟,她所提出的“景象说”,见解独到,成一家之言。她的短篇小说就是在此指导下的成功实践,不仅是对纷繁复杂的人生景象的呈现,而且通过诗性、智性和象征等个性化的表达,构建了短篇小说含蓄蕴藉、韵味隽永的艺术世界。

摘要：敦煌古代的画工画匠是敦煌艺术的创造者。敦煌文献中有一些关于敦煌古代画匠称谓的记录,本文分普通画匠与官吏画匠两类对这些文献进行了梳理和说明,指出古代文人赞颂画工的意义。