摘要：Advancing biotechnologies are revolutionizing not only health and medicine, but also many different sectors such as agriculture,energy, chemistry, and textiles. As synthetic biology is leveraged as a programmable platform for the creation and biodesign ofhigh-value biological medicines, foods, and commodities, the world is facing new territory in terms of ensuring the safety andsecurity of both novel and engineered biological organisms, as well as the biological and digital platforms in which they aredesigned. Biosecurity practices and policies have traditionally revolved around preventing the misuse of biological pathogens,primarily through controlling access to pathogens. The advent of biodesign capabilities, such as gene editors, gene synthesiscapabilities, and genetic engineering, requires a reevaluation of traditional biosecurity policies to mitigate risks associated withsuch engineering of biological entities. Here, features of “Biosecurity by Design” approaches are described, including theapplication of risk/benefit analysis and risk mitigation, post-COVID opportunities, and ethical global norms in the progressionof biodesign and growing bioeconomies.