摘要：In this study,boron-doped hydroxyapatite(BHT)-loaded alginate/gelatin-based(A/G)hydrogel coating on Ti was fabricated to support bone integration through triggering osteoinduction,vascularization and ***,highly reproducible,cheap and time-effective BHT was produced,which significantly promoted higher osteogenic and angiogenic maturation,while a mild innate immune response was *** immense potential of BHT was evidenced by the production of a gap-filling A/G/BHT interphase on Ti implants to mimic the osseous extracellular matrix to achieve functional bridging and exert control over the course of innate immune *** initially aminosilanized the implant surface using 3-aminopropyl triethoxysilane,and then coated it with 0.25%w/v alginate with 20 mM 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide and N-hydroxysuccinimide to allowthe A/G/BHT pre-gel to disperse evenly and covalently attach on the *** pre-gel was added with 0.2 M NaCl to homogeneously blend BHT in the structure without inducing ionic ***,the coated implants were freeze-dried and *** coated layer demonstrated high cohesive and adhesive strength,and 8-month-long shelf-life at room temperature and normal *** A/G/BHT was able to coat an irregularly shaped Ti *** and endothelial cells thrived on the A/G/BHT,and it demonstrated greatly improved osteogenic and angiogenic ***,A/G/BHT maintained macrophage viability and generated an acute increase in immune response that could be resolved ***,A/G/BHT was shown to induce the robust integration of implant in a rabbit femur osteochondral model within ***,we concluded that A/G/BHT coatings could serve as amultifunctional reservoir,promoting the strong and rapid osseointegration of metallic implants.