摘要：利用二氯二茂锆与4,4′-(蒽-9,10-二基)二苯甲酸自组装制备了一种锆基金属有机四面体(ZrT-6),并将其应用于过氧草酸酯类化学发光的研究,发现其在发光强度和寿命方面均优于所使用的配体.更重要的是,ZrT-6在化学发光过程中保持了良好的稳定性,为其进一步的实际应用打下了坚实的基础.该工作对过氧草酸酯类化学发光系统的设计具有借鉴意义.

摘要：Starting from 4,6-dimethyl-2-oxo-(1H)-3-pyridinecarbonitrile 1 and 3-aminopyrazolopyridine 4, a series of cyanopyri- dine derivatives 3a-i, Schiff bases 5a-f, urea and thiourea derivatives 6a-b, amide derivatives 7a-h, pyridopyra- zolopy-rimidine 8a-b and pyridopyrazolotriazine 10a-b were synthesized. Activities of eleven representative compounds were evaluated against A-549 (lung), HEPG2 (liver) and HCT-116 (colon) cancer cell lines. The findings revealed that some of the synthesized compounds showed remarkable anticancer activities, especially 8b which displayed the highest activity among the tested compounds with IC50 equal to 2.9, 2.6 and 2.3 μmol. In addition to synthesis and biological activities, we present discussion about the rationale of the design and activity of the potent compound 8b using struc- ture-based modeling tools.

摘要：本文介绍在结构优化设计中考虑疲劳寿命要求的一种方法。其基本原理是在优化过程中应用载荷历程数据和结构有限元应力以及材料的疲劳特性计算疲劳寿命。此寿命要求被认为是边界约束,而结构重量被看作是目标函数。为了论证这一原理,讨论了考虑疲劳寿命制约的优化任务和基于现代方法的疲劳寿命计算。文中介绍了一些优化设计试例,其中使用了美国汽车工程师学会(SAE)有切口试样试验的疲劳数据。