摘要：Hypoxia severely impedes the therapeutic efficacies of tumor chemotherapy, radiotherapy and conventional photodynamic therapy(type Ⅱ PDT). Herein, we proposed a nonplanar near-infrared(NIR)-absorbing hyperthermia and superoxide radical(O^(-)_(2)) photogenerator(TB) against hypoxic tumors. TB particularly possessed a favorable O^(-)_(2) generation capability under 808 nm laser irradiation with the donoracceptor-donor(D-A-D) molecular structure. Moreover, owing to molecular rotation, potent hyperthermia was realized under continuous laser irradiation. For the usage of hypoxic tumor treatment, TB was encapsulated by a block copolymer,poly(ethylene glycol)-b-poly(latic acid)(PEG_(45)-b-PLA_(24)), to fabricate phototheranostic nanoparticles(TB NPs). Due to the twisted molecular structure and the shielding effect of long alkyl chains, the π-π stacking-induced quenching of O^(-)_(2) could be reduced after the fabrication of nano-assemblies. Significantly, TB NPs exhibited satisfactory O^(-)_(2) generation for type I PDT and a simultaneously distinct photothermal conversion efficiency(PCE, 62%) for photothermal therapy(PTT)to combat hypoxic tumor cells. Moreover, the high PCE endowed TB NPs with high-performance photoacoustic(PA)and photothermal imaging capability. In vivo experiments demonstrated that TB NPs possessed an outstanding phototherapeutic efficacy for eradicating hypoxic tumors. This study established a novel approach for constructing oxygenindependent phototherapeutic reagent against hypoxic tumors.