摘要：Novel histone deacetylase （HDAC） inhibitors 9a-1 were designed and synthesized by coupling the carboxyl group of salicylic acid （SA） with N-hydroxycinnamamides through various alkylol amines, and their in vitro biological activities were evaluated. The N-hydroxycinnamamide/SA hybrids 9b-f and 9h showed good to moderate anti-tumor activities. Notably, compound 9e had a greater potency, comparable to vorinostat （SAHA）, in human colon carcinoma cells, which was probably, or at least partially, attributable to the positive effects of the chain length noted in allojlol amines. Furthermore, the HDAC inhibitory activities of 9e against Hela cell nuclear were also similar to that of vorinostat （SAHA）, while the tested compounds 9c-f did not exhibit any isoform selectivity in the inhibition of HDACs. In addition, compound 9e could selectively inhibit tumor cells, but not inhibit non-tumor cell proliferation in vitro. Our findings suggest that the N-hydroxycinnamamide/SA hybrids may hold significant promise as therapeutic a^ents for the intervention of human cancers.

摘要：防波堤在地质条件及堤身断面基本确定前提下,堤顶高程是影响防波堤造价的主要因素之一。本文对中美标准下滨海电厂防波堤堤顶标高确定方法进行比较,分析两者的共同点及差异,总结经验,为涉外工程设计做好技术储备。

摘要：为消除单体性能差异对动力电池组的影响,针对现有的电池均衡方法,提出了一种在线均衡控制策略,设计了多电平桥臂电路与单体电池并联,采用冗余设计,通过控制多电平桥臂电路状态,实现单体电池的接入或旁路,采用合理的控制策略,使动力电池组在充放电过程中,各单体电池实时保持一致,实验结果证明了该方法的有效性。

摘要：高通量表征技术在金属材料分析领域具有重要应用价值,它能够实现对金属材料进行跨尺度的全域分析,评价材料表面宏观特性、微观不均匀性及局部缺陷。辉光放电溅射可沿样品表面的纵深方向,以大尺寸、平坦且快速的方式逐层剥蚀样品,再将暴露出真实显微组织的样品送至多种分析仪器中进行成分、性能、组织结构的分析,从而作为金属材料的高通量表征样品前处理环节的关键设备。在传统Grimm型辉光溅射源的基础上,本研究搭建了一种专为高通量实验设计的辉光放电溅射系统,该系统将辉光溅射尺度由mm级扩展至cm级,同时实验发现了大尺寸溅射会导致辉光放电强度及溅射速率降低这一现象。针对这一现象,结合通过COMSOL Multiphysics仿真计算的辉光放电电子运动轨迹、电子密度以及化学反应速率等结果,该研究提出了一种通过施加扫描磁场来增强辉光放电光谱(GD-OES)强度以及溅射速率的方法。实验选用T2紫铜样品来探究扫描磁场的增强效果,结果表明,应用扫描磁场增强装置可获得更强的光谱信号强度及更快的溅射速率。在保持放电电压和电流不变的前提下,Mo、Cu元素的光谱强度分别增至无磁场时的1.43~11.97倍和1.13~26.50倍。其中,Mo元素光谱强度最大值可达53421 Cts,Cu元素光谱强度最大值可达76948 Cts,分别是无磁场时的6.86倍、4.32倍。此外,该方法可以显著地提高溅射速率,当阳极筒孔径为?15 mm时,T2紫铜样品的溅射速率提高了4.35倍,最高可达2662.09 nm·min^(-1)。使用白光干涉仪和金相显微镜对溅射坑表面的平整度和显微组织图像进行了采集,结果显示磁场引入对溅射坑表面粗糙度未产生显著影响,同时能清晰地呈现样品的真实显微组织特征。综上,实验结果证实,应用扫描磁场增强装置可在确保溅射平整度不受影响的前提下,实现光谱信号强度和溅射速率的提升,为解决大尺寸溅射引起的低溅射速率问题提供了新方法。

摘要：We demonstrate a technique of temperature compensation for 1.3μm InAs/GaAs quantum-dot(QD)lasers by facet coating *** key point of the technique is to make sure that the mirror loss of the lasers decreases as the temperature *** realize this,we design a type of facet coating by shifting the central wavelength of the facet coating from 1310nm to 1480nm,whose reflectivity increases as the emission wavelength of the lasers ***,the laser with the new facet coating exhibits a characteristic temperature doubled in size and a more stable slope efficiency in the temperature range from 10℃to 70℃,compared with the traditional one with a temperature-independent mirror loss.

摘要：There is a comm on sense view for atomic magnetometers that their spin-projection-noises(SPNs) are inversely proportional to (T_2)^(1/2), where (T_2)^(1/2) is the transverse relaxation time. We analyze the current atomic magnetometer types and give a counter-example of this common sense, which is the all-optical spin precession modulated threeaxis atomic magnetometer proposed by our group in 2015. Unlike the other atomic magnetometers, the SPN of this kind of atomic magnetometers is proportional to (T_2)^(1/2) due to the fact that the scale factor between P_x and B can be unrelated to the transverse relaxation time T_2. We demonstrate this irrelevance experimentally and analyze the SPN theoretically. Using short-pulse ultra-high power laser to fully polarize the atoms, the phenomenon that SPN decreases with T_2 may also be demonstrated experimentally and a new tool for researching SPN in atomic magnetometers may be realized.

摘要：Four hitherto unknown 6a,11b-dihydroxypterocarpans,namely pterocarpadiols A–D(1–4),were isolated from the ethanol extract of the twigs and leaves of Derris *** structures were elucidated on the basis of extensive spectroscopic *** A–D are a kind of very rare 6a,11b-dihydroxypterocarpans,and their presence as markers may be helpful in chemotaxonomical classification.

摘要：Through a great deal calculation, the design and simulation analysis of stator parametric and rotor electromagnetic system of 1000MW turbo-generator are performed by using Ansoft Maxwell Rmxprt12.1 software. Besides. the basic parameters of the generator, the geometry dimensions of the stator and rotor, type and sizes of the slots, coils and windings parameters and the way of windings connection are determined. The finite element model of electromagnetic systems of generator stator and rotor was constructed by Ansoft Maxwe112D3D 12.1, and the transient electromagnetic characteristics of generator was analyzed and simulated. The 3D geometric models of turbo-generator were established respectively by using PROE software, and the dynamic finite element model of generator structure was built by ANSYS workbench 11.0. In addition, the dynamic characteristics of stator iron core, stator frame were calculated respectively. The simulation calculation has shown that the structural parameters, material parameters, and the electromagnetic characteristics parameters for large turbogenerator that are put forward by this paper should be optimal. and the design plan and method suggested by this paper should be feasible. The paper provides an effective solution for the development of larger turbo-generator than 1000 MW.

摘要：针对CPM定价模型不能区分广告浏览效果的问题,将广告曝光时间作为浏览质量标准,建立一种新型基于浏览质量的CPV广告定价模型。采用MATLAB仿真分析方法,研究影响广告主和广告发布者定价模型(CPM或CPV)偏好的主要因素,即广告主浏览质量标准,网络用户浏览时间均值和标准差。结果表明:当浏览时间均值相同时,浏览时间标准差对两者模型偏好的作用大于浏览质量标准;当浏览质量标准相同时,浏览时间均值的作用大于浏览时间标准差;将3个因素对广告主和广告发布者模型偏好作用大小进行排序,则浏览时间均值作用最大,浏览时间标准差其次,浏览质量标准作用最小。

摘要：Porous SiC/Ti-based metallic glass composite (Ti-BMGC), a new kind of composite, has significant application prospectin the field of light armor. To evaluate the dynamic mechanical response of the composite, dynamic Vickers hardness andindentation-induced deformation behavior were investigated by comparison with that under static indentation. The dynamic hardnesswas measured by a modified split Hopkinson pressure bar (SHPB). The dynamic hardness is obviously greater than the statichardness. The brittleness parameter under dynamic indentation is also greater than that under static indentation. Although thedynamic indentation induced more severe deformation behavior than the static indentation, the deformation and fracturecharacteristics in the two loading cases are nearly the same, both exhibiting extensive cracks in the SiC phase and severe plasticdeformation in the metallic glass phase.